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pubmed-article:16861pubmed:abstractTextCarotid infusions of sodium cyanide solution and perfusions of hypoxemic or hypercapnic fetal blood were done before and after peripheral chemoreceptor denervation. Step changes in PaO2 ranged from -11 to -22 Torr; step changes in PaCO2 ranged from +17 to +42 Torr. The cyanide dose was 0.2 mg/kg per loop system. Control perfusions consisted of 25 ml of fetal blood without changes in pH and blood gases. A ventilatory response occurred in the majority of all experimental perfusions regardless of innervation status of the peripheral chemoreceptors. No response occurred with control perfusions. There was a marked variability in the time of onset of ventilatory activity with a delay of greater than 10 s occurring following most perfusions. These studies demonstrate that the fetus has an attenuated ventilatory response to chemical stimuli and that hypoxia stimulates ventilation in the absence of peripheral chemoreceptors.lld:pubmed
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pubmed-article:16861pubmed:articleTitleVentilatory response in the fetal lamb following peripheral chemodenervation.lld:pubmed
pubmed-article:16861pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:16861pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed