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pubmed-article:16856850pubmed:abstractTextHomologous recombination is essential for accurate chromosome segregation during meiosis in most sexual organisms. Meiotic recombination is initiated by the formation of DSBs (DNA double-strand breaks) made by the Spo11 protein. We review here recent findings pertaining to protein-protein interactions important for DSB formation, the mechanism of an early step in the processing of Spo11-generated DSBs, and regulation of DSB formation by protein kinases.lld:pubmed
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pubmed-article:16856850pubmed:authorpubmed-author:NealeM JMJlld:pubmed
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pubmed-article:16856850pubmed:articleTitleInitiation of meiotic recombination by formation of DNA double-strand breaks: mechanism and regulation.lld:pubmed
pubmed-article:16856850pubmed:affiliationMolecular Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Ave., Box 97, New York, NY 10021, USA. s-keeney@ski.mskcc.orglld:pubmed
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