| pubmed-article:16854083 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16854083 | lifeskim:mentions | umls-concept:C0027651 | lld:lifeskim |
| pubmed-article:16854083 | lifeskim:mentions | umls-concept:C0011923 | lld:lifeskim |
| pubmed-article:16854083 | lifeskim:mentions | umls-concept:C0027930 | lld:lifeskim |
| pubmed-article:16854083 | lifeskim:mentions | umls-concept:C0205360 | lld:lifeskim |
| pubmed-article:16854083 | pubmed:issue | 15 | lld:pubmed |
| pubmed-article:16854083 | pubmed:dateCreated | 2006-7-20 | lld:pubmed |
| pubmed-article:16854083 | pubmed:abstractText | A series of Gly-neurotensin(8-13) analogues modified at the N-terminus by acyclic tetraamines (Demotensin 1-4) were obtained by solid-phase peptide synthesis techniques. Strategic replacement of amino acids and/or reduction of sensitive peptide bonds were performed to enhance conjugate resistance against proteolytic enzymes. During 99mTc-labeling, single species radiopeptides, [99mTc]Demotensin 1-4, were easily obtained in high yields and typical specific activities of 1 Ci/micromol. Peptide conjugates displayed a high affinity binding to the human neurotensin subtype 1 receptor (NTS1-R) expressed in colon adenocarcinoma HT-29 or WiDr cells and/or in human tumor sections. [99mTc]Demotensin 1-4 internalized very rapidly in HT-29 or WiDr cells by a NTS1-R-mediated process. [99mTc]Demotensin 3 and 4, which remained stable during 1 h incubation in murine plasma, were selectively studied in nude mice bearing human HT-29 and WiDr xenografts. After injection, [99mTc]Demotensin 3 and 4 effectively and specifically localized in the experimental tumors and were rapidly excreted via the kidneys into the urine, exhibiting overall biodistribution patterns favorable for NTS1-R-targeted tumor imaging in man. | lld:pubmed |
| pubmed-article:16854083 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16854083 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16854083 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16854083 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16854083 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16854083 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16854083 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16854083 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16854083 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16854083 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16854083 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:16854083 | pubmed:issn | 0022-2623 | lld:pubmed |
| pubmed-article:16854083 | pubmed:author | pubmed-author:TourwéDirkD | lld:pubmed |
| pubmed-article:16854083 | pubmed:author | pubmed-author:ReubiJean-Cla... | lld:pubmed |
| pubmed-article:16854083 | pubmed:author | pubmed-author:ConrathPeterP | lld:pubmed |
| pubmed-article:16854083 | pubmed:author | pubmed-author:MainaTheodosi... | lld:pubmed |
| pubmed-article:16854083 | pubmed:author | pubmed-author:NikolopoulouA... | lld:pubmed |
| pubmed-article:16854083 | pubmed:author | pubmed-author:NockBerthold... | lld:pubmed |
| pubmed-article:16854083 | pubmed:author | pubmed-author:MaesVeronique... | lld:pubmed |
| pubmed-article:16854083 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16854083 | pubmed:day | 27 | lld:pubmed |
| pubmed-article:16854083 | pubmed:volume | 49 | lld:pubmed |
| pubmed-article:16854083 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16854083 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16854083 | pubmed:pagination | 4767-76 | lld:pubmed |
| pubmed-article:16854083 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:16854083 | pubmed:meshHeading | pubmed-meshheading:16854083... | lld:pubmed |
| pubmed-article:16854083 | pubmed:meshHeading | pubmed-meshheading:16854083... | lld:pubmed |
| pubmed-article:16854083 | pubmed:meshHeading | pubmed-meshheading:16854083... | lld:pubmed |
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| pubmed-article:16854083 | pubmed:meshHeading | pubmed-meshheading:16854083... | lld:pubmed |
| pubmed-article:16854083 | pubmed:meshHeading | pubmed-meshheading:16854083... | lld:pubmed |
| pubmed-article:16854083 | pubmed:meshHeading | pubmed-meshheading:16854083... | lld:pubmed |
| pubmed-article:16854083 | pubmed:meshHeading | pubmed-meshheading:16854083... | lld:pubmed |
| pubmed-article:16854083 | pubmed:meshHeading | pubmed-meshheading:16854083... | lld:pubmed |
| pubmed-article:16854083 | pubmed:meshHeading | pubmed-meshheading:16854083... | lld:pubmed |
| pubmed-article:16854083 | pubmed:meshHeading | pubmed-meshheading:16854083... | lld:pubmed |
| pubmed-article:16854083 | pubmed:meshHeading | pubmed-meshheading:16854083... | lld:pubmed |
| pubmed-article:16854083 | pubmed:meshHeading | pubmed-meshheading:16854083... | lld:pubmed |
| pubmed-article:16854083 | pubmed:meshHeading | pubmed-meshheading:16854083... | lld:pubmed |
| pubmed-article:16854083 | pubmed:meshHeading | pubmed-meshheading:16854083... | lld:pubmed |
| pubmed-article:16854083 | pubmed:meshHeading | pubmed-meshheading:16854083... | lld:pubmed |
| pubmed-article:16854083 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16854083 | pubmed:articleTitle | Toward stable N4-modified neurotensins for NTS1-receptor-targeted tumor imaging with 99mTc. | lld:pubmed |
| pubmed-article:16854083 | pubmed:affiliation | Institute of Radioisotopes - Radiodiagnostic Products, National Center for Scientific Research Demokritos, 15310 Athens, Greece. | lld:pubmed |
| pubmed-article:16854083 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16854083 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:16854083 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:16854083 | lld:chembl |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16854083 | lld:pubmed |
