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pubmed-article:16848642pubmed:abstractTextMolecular studies have led recently to the proposal of a new super-ordinal arrangement of the 18 extant Eutherian orders. From the four proposed super-orders, Afrotheria and Xenarthra were considered the most basal. Chromosome-painting studies with human probes in these two mammalian groups are thus key in the quest to establish the ancestral Eutherian karyotype. Although a reasonable amount of chromosome-painting data with human probes have already been obtained for Afrotheria, no Xenarthra species has been thoroughly analyzed with this approach. We hybridized human chromosome probes to metaphases of species (Dasypus novemcinctus, Tamandua tetradactyla, and Choloepus hoffmanii) representing three of the four Xenarthra families. Our data allowed us to review the current hypotheses for the ancestral Eutherian karyotype, which range from 2n = 44 to 2n = 48. One of the species studied, the two-toed sloth C. hoffmanii (2n = 50), showed a chromosome complement strikingly similar to the proposed 2n = 48 ancestral Eutherian karyotype, strongly reinforcing it.lld:pubmed
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pubmed-article:16848642pubmed:dateRevised2009-11-18lld:pubmed
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pubmed-article:16848642pubmed:articleTitleThe ancestral eutherian karyotype is present in Xenarthra.lld:pubmed
pubmed-article:16848642pubmed:affiliationComparative Molecular Cytogenetics Core, Genetics Branch, National Cancer Institute-Frederick, Frederick, Maryland, USA. svartmanm@hotmail.comlld:pubmed
pubmed-article:16848642pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:16848642pubmed:publicationTypeResearch Support, N.I.H., Intramurallld:pubmed
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