| pubmed-article:16825660 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16825660 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
| pubmed-article:16825660 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:16825660 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:16825660 | lifeskim:mentions | umls-concept:C0021853 | lld:lifeskim |
| pubmed-article:16825660 | lifeskim:mentions | umls-concept:C0039198 | lld:lifeskim |
| pubmed-article:16825660 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:16825660 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:16825660 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:16825660 | lifeskim:mentions | umls-concept:C0027586 | lld:lifeskim |
| pubmed-article:16825660 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:16825660 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:16825660 | pubmed:dateCreated | 2006-7-7 | lld:pubmed |
| pubmed-article:16825660 | pubmed:abstractText | This study determined whether Heligmosomoides polygyrus induces intestinal regulatory T cells. Splenic T cells proliferate strongly when cultured with anti-CD3 and antigen-presenting cells (APC). Lamina propria T cells from mice with H. polygyrus mixed with normal splenic T cells from uninfected mice inhibited proliferation over 90%. Lamina propria T cells from mice without H. polygyrus only modestly affected T cell proliferation. The worm-induced regulatory T cell was CD8+ and required splenic T cell contact to inhibit proliferation. The regulation also was IL-10 independent, but TAP-dependent, suggesting that it requires major histocompatibility complex (MHC) class I interaction. Additional studies employed mice with transgenic T cells that did not express functional TGF-beta receptors. The lamina propria T regulator inhibited proliferation of these transgenic T cells nearly 100%, suggesting that TGF-beta signaling via the T cell was not required. CD8+ T cells were needed for worms to reverse piroxicam-induced colitis in Rag mice (T and B cell deficient) reconstituted with IL-10-/- T cells. Thus H. polygyrus induces a regulatory CD8+ lamina propria T cell that inhibits T cell proliferation and that appears to have a role in control of colitis. | lld:pubmed |
| pubmed-article:16825660 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16825660 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16825660 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16825660 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16825660 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16825660 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16825660 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16825660 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16825660 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:16825660 | pubmed:issn | 0193-1857 | lld:pubmed |
| pubmed-article:16825660 | pubmed:author | pubmed-author:MetwaliAhmedA | lld:pubmed |
| pubmed-article:16825660 | pubmed:author | pubmed-author:BlumArthur... | lld:pubmed |
| pubmed-article:16825660 | pubmed:author | pubmed-author:ElliottDavid... | lld:pubmed |
| pubmed-article:16825660 | pubmed:author | pubmed-author:WeinstockJoel... | lld:pubmed |
| pubmed-article:16825660 | pubmed:author | pubmed-author:HangLongL | lld:pubmed |
| pubmed-article:16825660 | pubmed:author | pubmed-author:UrbanJosephJ | lld:pubmed |
| pubmed-article:16825660 | pubmed:author | pubmed-author:SetiawanTommy... | lld:pubmed |
| pubmed-article:16825660 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16825660 | pubmed:volume | 291 | lld:pubmed |
| pubmed-article:16825660 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16825660 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16825660 | pubmed:pagination | G253-9 | lld:pubmed |
| pubmed-article:16825660 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:16825660 | pubmed:meshHeading | pubmed-meshheading:16825660... | lld:pubmed |
| pubmed-article:16825660 | pubmed:meshHeading | pubmed-meshheading:16825660... | lld:pubmed |
| pubmed-article:16825660 | pubmed:meshHeading | pubmed-meshheading:16825660... | lld:pubmed |
| pubmed-article:16825660 | pubmed:meshHeading | pubmed-meshheading:16825660... | lld:pubmed |
| pubmed-article:16825660 | pubmed:meshHeading | pubmed-meshheading:16825660... | lld:pubmed |
| pubmed-article:16825660 | pubmed:meshHeading | pubmed-meshheading:16825660... | lld:pubmed |
| pubmed-article:16825660 | pubmed:meshHeading | pubmed-meshheading:16825660... | lld:pubmed |
| pubmed-article:16825660 | pubmed:meshHeading | pubmed-meshheading:16825660... | lld:pubmed |
| pubmed-article:16825660 | pubmed:meshHeading | pubmed-meshheading:16825660... | lld:pubmed |
| pubmed-article:16825660 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16825660 | pubmed:articleTitle | Induction of CD8+ regulatory T cells in the intestine by Heligmosomoides polygyrus infection. | lld:pubmed |
| pubmed-article:16825660 | pubmed:affiliation | Department of Internal Medicine, University of Iowa, Iowa City, USA. | lld:pubmed |
| pubmed-article:16825660 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16825660 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16825660 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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