| pubmed-article:1682281 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1682281 | lifeskim:mentions | umls-concept:C0020094 | lld:lifeskim |
| pubmed-article:1682281 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
| pubmed-article:1682281 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:1682281 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:1682281 | lifeskim:mentions | umls-concept:C1742737 | lld:lifeskim |
| pubmed-article:1682281 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:1682281 | pubmed:dateCreated | 1991-12-13 | lld:pubmed |
| pubmed-article:1682281 | pubmed:abstractText | A human T-cell line producing human T-cell leukemia virus type I (HTLV-I), MT-2, was injected intravenously into female F344 rats aged 5 weeks to make HTLV-I carrier rats. Antibody against HTLV-I was detected at the 5th week after MT-2 injection, and its titer reached a high plateau which continued from the 15th to the 27th week. The antibodies were against p19, p24, p28 and p53 of HTLV-I antigens from MT-2 cells. The gag, pX and LTR nucleotide sequences of HTLV-I provirus were demonstrated by using polymerase chain reaction (PCR) in the peripheral-blood mononuclear cells of 3 rats at the 44th week and 2 at the 66th to 68th week out of 8 F344 rats injected with MT-2 cells. Quantification of the HTLV-I proviral sequence revealed that 30 to 60 molecules were present in 10(5) peripheral-blood mononuclear cells, indicating that the rats were chronically infected with HTLV-I. HTLV-I-infected rats could serve as a small-animal model for studying the pathophysiological state of HTLV-I carriers and also that of HTLV-I infection on various HTLV-I-related diseases, including adult T-cell leukemia and HTLV-I-associated myelopathy. | lld:pubmed |
| pubmed-article:1682281 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1682281 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1682281 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1682281 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1682281 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1682281 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1682281 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1682281 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:1682281 | pubmed:issn | 0020-7136 | lld:pubmed |
| pubmed-article:1682281 | pubmed:author | pubmed-author:SugaTT | lld:pubmed |
| pubmed-article:1682281 | pubmed:author | pubmed-author:UchidaMM | lld:pubmed |
| pubmed-article:1682281 | pubmed:author | pubmed-author:UchidaKK | lld:pubmed |
| pubmed-article:1682281 | pubmed:author | pubmed-author:TanakaHH | lld:pubmed |
| pubmed-article:1682281 | pubmed:author | pubmed-author:ShimotohnoKK | lld:pubmed |
| pubmed-article:1682281 | pubmed:author | pubmed-author:KameyamaTT | lld:pubmed |
| pubmed-article:1682281 | pubmed:author | pubmed-author:MatsumuraMM | lld:pubmed |
| pubmed-article:1682281 | pubmed:author | pubmed-author:KinoshitaTT | lld:pubmed |
| pubmed-article:1682281 | pubmed:author | pubmed-author:KushidaSS | lld:pubmed |
| pubmed-article:1682281 | pubmed:author | pubmed-author:AlyJJ | lld:pubmed |
| pubmed-article:1682281 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1682281 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:1682281 | pubmed:volume | 49 | lld:pubmed |
| pubmed-article:1682281 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1682281 | pubmed:authorsComplete | N | lld:pubmed |
| pubmed-article:1682281 | pubmed:pagination | 764-9 | lld:pubmed |
| pubmed-article:1682281 | pubmed:dateRevised | 2007-7-24 | lld:pubmed |
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| pubmed-article:1682281 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1682281 | pubmed:articleTitle | Infection of rats with HTLV-1: a small-animal model for HTLV-1 carriers. | lld:pubmed |
| pubmed-article:1682281 | pubmed:affiliation | Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan. | lld:pubmed |
| pubmed-article:1682281 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1682281 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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