| pubmed-article:16818781 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16818781 | lifeskim:mentions | umls-concept:C0021368 | lld:lifeskim |
| pubmed-article:16818781 | lifeskim:mentions | umls-concept:C0075290 | lld:lifeskim |
| pubmed-article:16818781 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:16818781 | pubmed:dateCreated | 2006-7-4 | lld:pubmed |
| pubmed-article:16818781 | pubmed:abstractText | Severe infections with Streptococcus pyogenes, an important human pathogen, are associated with massive inflammatory reactions in the human host. Here we show that streptococcal M protein interacts with TLR2 on human peripheral blood monocytes. As a consequence, monocytes express the cytokines IL-6, IL-1beta, and TNF-alpha. This response is significantly increased in the presence of neutrophil-derived heparin-binding protein (HBP), which co-stimulates monocytes by interacting with CD11/CD18. Analysis of tissue biopsies from patients with necrotizing fasciitis revealed recruitment of neutrophils and monocytes to the infectious site, combined with the release of HBP. The results show that M protein, in synergy with HBP, evokes an inflammatory response that may contribute to the profound pathophysiological consequences seen in severe streptococcal infections. | lld:pubmed |
| pubmed-article:16818781 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16818781 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16818781 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:16818781 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16818781 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16818781 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16818781 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16818781 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16818781 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16818781 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16818781 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16818781 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:16818781 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:16818781 | pubmed:author | pubmed-author:MörgelinMatth... | lld:pubmed |
| pubmed-article:16818781 | pubmed:author | pubmed-author:BjörckLarsL | lld:pubmed |
| pubmed-article:16818781 | pubmed:author | pubmed-author:SchumannRalf... | lld:pubmed |
| pubmed-article:16818781 | pubmed:author | pubmed-author:HerwaldHeikoH | lld:pubmed |
| pubmed-article:16818781 | pubmed:author | pubmed-author:RiesbeckKrist... | lld:pubmed |
| pubmed-article:16818781 | pubmed:author | pubmed-author:LindbomLennar... | lld:pubmed |
| pubmed-article:16818781 | pubmed:author | pubmed-author:Norrby-Teglun... | lld:pubmed |
| pubmed-article:16818781 | pubmed:author | pubmed-author:JohanssonLind... | lld:pubmed |
| pubmed-article:16818781 | pubmed:author | pubmed-author:RussellWayneW | lld:pubmed |
| pubmed-article:16818781 | pubmed:author | pubmed-author:EckertJanaJ | lld:pubmed |
| pubmed-article:16818781 | pubmed:author | pubmed-author:SoehnleinOliv... | lld:pubmed |
| pubmed-article:16818781 | pubmed:author | pubmed-author:PåhlmanLisa... | lld:pubmed |
| pubmed-article:16818781 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16818781 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:16818781 | pubmed:volume | 177 | lld:pubmed |
| pubmed-article:16818781 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16818781 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16818781 | pubmed:pagination | 1221-8 | lld:pubmed |
| pubmed-article:16818781 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:16818781 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16818781 | pubmed:articleTitle | Streptococcal M protein: a multipotent and powerful inducer of inflammation. | lld:pubmed |
| pubmed-article:16818781 | pubmed:affiliation | Department of Clinical Sciences, Section for Clinical and Experimental Infection Medicine, Biomedicinskt Centrum B14, Lund University, Tornavägen 10, SE-221 84 Lund, Sweden. | lld:pubmed |
| pubmed-article:16818781 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16818781 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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