| pubmed-article:16818231 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16818231 | lifeskim:mentions | umls-concept:C1166721 | lld:lifeskim |
| pubmed-article:16818231 | lifeskim:mentions | umls-concept:C0111429 | lld:lifeskim |
| pubmed-article:16818231 | lifeskim:mentions | umls-concept:C0597298 | lld:lifeskim |
| pubmed-article:16818231 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:16818231 | lifeskim:mentions | umls-concept:C1519751 | lld:lifeskim |
| pubmed-article:16818231 | lifeskim:mentions | umls-concept:C0332256 | lld:lifeskim |
| pubmed-article:16818231 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:16818231 | lifeskim:mentions | umls-concept:C1705294 | lld:lifeskim |
| pubmed-article:16818231 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:16818231 | pubmed:dateCreated | 2006-7-4 | lld:pubmed |
| pubmed-article:16818231 | pubmed:abstractText | Cyclin E, an activator of cyclin-dependent kinase 2 (Cdk2), is targeted for proteasomal degradation by phosphorylation-dependent multiubiquitylation via the ubiquitin ligase SCF(hCdc4). SCF ubiquitin ligases are composed of a core of conserved subunits and one variable subunit (an F box protein) involved in substrate recognition. We show here that multiubiquitylation of cyclin E requires the sequential function of two distinct splice variant isoforms of the F box protein hCdc4 known as alpha and gamma. SCF(hCdc4alpha) binds a complex containing cyclin E, Cdk2, and the prolyl cis/trans isomerase Pin1 and promotes the activity of Pin1 without directly ubiquitylating cyclin E. However, due to the action of this SCF(hCdc4alpha)-Pin1 complex, cyclin E becomes an efficient ubiquitylation substrate of SCF(hCdc4gamma). Furthermore, in the context of Cdc4alpha and cyclin E, mutational data suggest that Pin1 isomerizes a noncanonical proline-proline bond, with the possibility that Cdc4alpha may serve as a cofactor for altering the specificity of Pin1. | lld:pubmed |
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| pubmed-article:16818231 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16818231 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16818231 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16818231 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16818231 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16818231 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:16818231 | pubmed:issn | 1097-2765 | lld:pubmed |
| pubmed-article:16818231 | pubmed:author | pubmed-author:MeansAnthony... | lld:pubmed |
| pubmed-article:16818231 | pubmed:author | pubmed-author:SangfeltOlleO | lld:pubmed |
| pubmed-article:16818231 | pubmed:author | pubmed-author:van... | lld:pubmed |
| pubmed-article:16818231 | pubmed:author | pubmed-author:ReedSteven... | lld:pubmed |
| pubmed-article:16818231 | pubmed:author | pubmed-author:YehElizabethE | lld:pubmed |
| pubmed-article:16818231 | pubmed:author | pubmed-author:MatskovaLudmi... | lld:pubmed |
| pubmed-article:16818231 | pubmed:author | pubmed-author:MalyukovaAljo... | lld:pubmed |
| pubmed-article:16818231 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16818231 | pubmed:day | 7 | lld:pubmed |
| pubmed-article:16818231 | pubmed:volume | 23 | lld:pubmed |
| pubmed-article:16818231 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16818231 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16818231 | pubmed:pagination | 37-48 | lld:pubmed |
| pubmed-article:16818231 | pubmed:dateRevised | 2011-5-23 | lld:pubmed |
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| pubmed-article:16818231 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16818231 | pubmed:articleTitle | Ubiquitylation of cyclin E requires the sequential function of SCF complexes containing distinct hCdc4 isoforms. | lld:pubmed |
| pubmed-article:16818231 | pubmed:affiliation | Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA. | lld:pubmed |
| pubmed-article:16818231 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16818231 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16818231 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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