| pubmed-article:16798807 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16798807 | lifeskim:mentions | umls-concept:C0008377 | lld:lifeskim |
| pubmed-article:16798807 | lifeskim:mentions | umls-concept:C0037906 | lld:lifeskim |
| pubmed-article:16798807 | lifeskim:mentions | umls-concept:C0439962 | lld:lifeskim |
| pubmed-article:16798807 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:16798807 | lifeskim:mentions | umls-concept:C0039476 | lld:lifeskim |
| pubmed-article:16798807 | lifeskim:mentions | umls-concept:C0439857 | lld:lifeskim |
| pubmed-article:16798807 | lifeskim:mentions | umls-concept:C0486616 | lld:lifeskim |
| pubmed-article:16798807 | lifeskim:mentions | umls-concept:C0112912 | lld:lifeskim |
| pubmed-article:16798807 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:16798807 | pubmed:dateCreated | 2006-8-30 | lld:pubmed |
| pubmed-article:16798807 | pubmed:abstractText | The kinetics of carboxyfluorescein efflux induced by the amphipathic peptide delta-lysin from vesicles of porcine brain sphingomyelin (BSM), 1-palmitoyl-2-oleoyl-phosphatidylcholine (POPC), and cholesterol (Chol) were investigated as a function of temperature and composition. Sphingomyelin (SM)/Chol mixtures form a liquid-ordered (L(o)) phase whereas POPC exists in the liquid-disordered (L(d)) phase at ambient temperature. delta-Lysin binds strongly to L(d) and poorly to L(o) phase. In BSM/Chol/POPC vesicles the rate of carboxyfluorescein efflux induced by delta-lysin increases as the POPC content decreases. This is explained by the increase of delta-lysin concentration in L(d) domains, which enhances membrane perturbation by the peptide. Phase separations in the micrometer scale have been observed by fluorescence microscopy in SM/Chol/POPC mixtures for some SM, though not for BSM. Thus, delta-lysin must detect heterogeneities (domains) in BSM/Chol/POPC on a much smaller scale. Advantage was taken of the inverse variation of the efflux rate with the L(d) content of BSM/Chol/POPC vesicles to estimate the L(d) fraction in those mixtures. These results were combined with differential scanning calorimetry to obtain the BSM/Chol/POPC phase diagram as a function of temperature. | lld:pubmed |
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| pubmed-article:16798807 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16798807 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16798807 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16798807 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16798807 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:16798807 | pubmed:issn | 0006-3495 | lld:pubmed |
| pubmed-article:16798807 | pubmed:author | pubmed-author:HinderliterAn... | lld:pubmed |
