| pubmed-article:16784491 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16784491 | lifeskim:mentions | umls-concept:C0040113 | lld:lifeskim |
| pubmed-article:16784491 | lifeskim:mentions | umls-concept:C0034790 | lld:lifeskim |
| pubmed-article:16784491 | lifeskim:mentions | umls-concept:C1515126 | lld:lifeskim |
| pubmed-article:16784491 | lifeskim:mentions | umls-concept:C1515926 | lld:lifeskim |
| pubmed-article:16784491 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:16784491 | pubmed:dateCreated | 2006-6-20 | lld:pubmed |
| pubmed-article:16784491 | pubmed:abstractText | The majority of thymocytes die in the thymus, whereas small populations of T cells that are able to specifically recognize an antigen are considered to survive. Although the thymic selection is thought to have a profound effect on T-cell receptor (TCR) repertoire, little is known how TCR repertoire is formed during the thymocyte developmental process. We examined TCRalpha- and beta-chain variable regions (TCRAV and TCRBV) repertoire in thymic T-cell subpopulations from mice bearing different major histocompatibility (MHC) haplotypes. In Balb/c mice, but not C57BL/6, remarkable alterations of the TCR repertoire were observed in mature T-cell subpopulations as previously reported. In contrast, there were no significant differences of TCRBV repertoire between DN3 (CD25(+)CD44(-)) and DN4 (CD25(-)CD44(-)), and between DN4 and DP. These results suggest that (1) TCR repertoire of mature T cells was formed mainly under the influence of endogenous superantigens, while MHC haplotypes played the least role; (2) the 'beta-selection' process during immature stages had little impact on TCRBV repertoire formation; and (3) TCR repertoire in immature T-cell subpopulations was extremely similar between different strains of mice. We thus consider that pre-selection TCR repertoire in immature T cells could be determined by some genetic factors conserved among different strains. | lld:pubmed |
| pubmed-article:16784491 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16784491 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16784491 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16784491 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16784491 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16784491 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:16784491 | pubmed:issn | 0300-9475 | lld:pubmed |
| pubmed-article:16784491 | pubmed:author | pubmed-author:OgataMM | lld:pubmed |
| pubmed-article:16784491 | pubmed:author | pubmed-author:LUNTM RMR | lld:pubmed |
| pubmed-article:16784491 | pubmed:author | pubmed-author:SuzukiRR | lld:pubmed |
| pubmed-article:16784491 | pubmed:author | pubmed-author:YoshiokaTT | lld:pubmed |
| pubmed-article:16784491 | pubmed:author | pubmed-author:OhmoriTT | lld:pubmed |
| pubmed-article:16784491 | pubmed:author | pubmed-author:MatsutaniTT | lld:pubmed |
| pubmed-article:16784491 | pubmed:author | pubmed-author:SogaHH | lld:pubmed |
| pubmed-article:16784491 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16784491 | pubmed:volume | 64 | lld:pubmed |
| pubmed-article:16784491 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16784491 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16784491 | pubmed:pagination | 53-60 | lld:pubmed |
| pubmed-article:16784491 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:16784491 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16784491 | pubmed:articleTitle | Alteration of T-cell receptor repertoires during thymic T-cell development. | lld:pubmed |
| pubmed-article:16784491 | pubmed:affiliation | Division of Immunology and Embryology, Department of Cell Biology, Tohoku University School of Medicine, Sendai, Japan. matsu@immem.med.tohoku.ac.jp | lld:pubmed |
| pubmed-article:16784491 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16784491 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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