| pubmed-article:16783021 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16783021 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:16783021 | lifeskim:mentions | umls-concept:C0002085 | lld:lifeskim |
| pubmed-article:16783021 | lifeskim:mentions | umls-concept:C1149630 | lld:lifeskim |
| pubmed-article:16783021 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:16783021 | pubmed:dateCreated | 2006-8-24 | lld:pubmed |
| pubmed-article:16783021 | pubmed:abstractText | The establishment of transcriptional silencing in yeast requires cell-cycle progression, but the nature of this requirement is unknown. Sir2 is a protein deacetylase that is required for gene silencing in yeast. We have used temperature-sensitive alleles of the SIR2 gene to assess Sir2's contribution to silencing as a function of the cell cycle. When examined in vivo, these conditional alleles fall into two classes: one class exhibits a loss of silencing when raised to the nonpermissive temperature regardless of cell-cycle position, while the second class exhibits a mitosis-specific silencing defect. Alleles of the first class have a primary defect in protein deacetylase activity, while the alleles of the second class are specifically defective in Sir2-Sir4 interactions at nonpermissive temperatures. Using a SIR2 temperature-sensitive allele, we show that silencing can be established at the HML locus during progression through the G2/M-G1 interval. These results suggest that yeast heterochromatin undergoes structural transitions as a function of the cell cycle and support the existence of a critical assembly step for silent chromatin in mitosis. | lld:pubmed |
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| pubmed-article:16783021 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:16783021 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16783021 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16783021 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:16783021 | pubmed:issn | 0016-6731 | lld:pubmed |
| pubmed-article:16783021 | pubmed:author | pubmed-author:MoazedDaneshD | lld:pubmed |
| pubmed-article:16783021 | pubmed:author | pubmed-author:MatecicMirela... | lld:pubmed |
| pubmed-article:16783021 | pubmed:author | pubmed-author:HolmesScott... | lld:pubmed |
| pubmed-article:16783021 | pubmed:author | pubmed-author:Martins-Taylo... | lld:pubmed |
| pubmed-article:16783021 | pubmed:author | pubmed-author:HickmanMerrit... | lld:pubmed |
| pubmed-article:16783021 | pubmed:author | pubmed-author:TannyJasonJ | lld:pubmed |
| pubmed-article:16783021 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16783021 | pubmed:volume | 173 | lld:pubmed |
| pubmed-article:16783021 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16783021 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16783021 | pubmed:pagination | 1939-50 | lld:pubmed |
| pubmed-article:16783021 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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