| pubmed-article:16773074 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16773074 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:16773074 | lifeskim:mentions | umls-concept:C0024623 | lld:lifeskim |
| pubmed-article:16773074 | lifeskim:mentions | umls-concept:C0246415 | lld:lifeskim |
| pubmed-article:16773074 | lifeskim:mentions | umls-concept:C0205390 | lld:lifeskim |
| pubmed-article:16773074 | lifeskim:mentions | umls-concept:C0879262 | lld:lifeskim |
| pubmed-article:16773074 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:16773074 | lifeskim:mentions | umls-concept:C0205179 | lld:lifeskim |
| pubmed-article:16773074 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:16773074 | pubmed:dateCreated | 2006-6-14 | lld:pubmed |
| pubmed-article:16773074 | pubmed:abstractText | The aims of this phase I/II study of docetaxel and S-1 were to determine the dose-limiting toxicity (DLT), maximum-tolerated dose (MTD), and recommended dose (RD) in the phase I part and to explore the tumour response, survival and safety in the phase II part. Patients with histologically- or cytologically confirmed unresectable or recurrent gastric cancer were eligible. Treatment consisted of intravenous docetaxel on day 1 (starting dose 50 mg m(-2)) and oral S-1 at a fixed dose of 40 mg m(-2) twice daily on days 1-14, every 4 weeks up to six cycles. Nine patients took part in the phase I portion of the study. The MTD of docetaxel was determined to be 50 mg m(-2), with the DLTs of grade 3 infection associated with grade 3 neutropenia and grade 4 neutropenia during S-1 administration. The RD of docetaxel was 40 mg m(-2) in combination with S-1 40 mg m(-2) b.i.d. The efficacy and safety of this regimen was therefore assessed in 46 patients with at least one measurable lesion. The overall response rate and estimated median overall survival were 46% (95% CI, 31-61%) and 14.0 months (8.3-17.3 months), respectively. The most common grade 3/4 toxicity was neutropenia (67% of patients), which was predictable and manageable. This regimen showed promising activity with moderate toxicities in advanced gastric cancer. | lld:pubmed |
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| pubmed-article:16773074 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16773074 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16773074 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16773074 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16773074 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16773074 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:16773074 | pubmed:issn | 0007-0920 | lld:pubmed |
| pubmed-article:16773074 | pubmed:author | pubmed-author:KatoTT | lld:pubmed |
| pubmed-article:16773074 | pubmed:author | pubmed-author:YamaguchiKK | lld:pubmed |
| pubmed-article:16773074 | pubmed:author | pubmed-author:MaedaYY | lld:pubmed |
| pubmed-article:16773074 | pubmed:author | pubmed-author:NakanoSS | lld:pubmed |
| pubmed-article:16773074 | pubmed:author | pubmed-author:MiyataYY | lld:pubmed |
| pubmed-article:16773074 | pubmed:author | pubmed-author:DoiTT | lld:pubmed |
| pubmed-article:16773074 | pubmed:author | pubmed-author:EsakiTT | lld:pubmed |
| pubmed-article:16773074 | pubmed:author | pubmed-author:SakataYY | lld:pubmed |
| pubmed-article:16773074 | pubmed:author | pubmed-author:TakiuchiHH | lld:pubmed |
| pubmed-article:16773074 | pubmed:author | pubmed-author:KomatsuYY | lld:pubmed |
| pubmed-article:16773074 | pubmed:author | pubmed-author:ShimamuraTT | lld:pubmed |
| pubmed-article:16773074 | pubmed:author | pubmed-author:SaitohSS | lld:pubmed |
| pubmed-article:16773074 | pubmed:author | pubmed-author:AkiyaTT | lld:pubmed |
| pubmed-article:16773074 | pubmed:author | pubmed-author:MunakataMM | lld:pubmed |
| pubmed-article:16773074 | pubmed:author | pubmed-author:KinjoFF | lld:pubmed |
| pubmed-article:16773074 | pubmed:author | pubmed-author:HyodoII | lld:pubmed |
| pubmed-article:16773074 | pubmed:author | pubmed-author:KoizumiWW | lld:pubmed |
| pubmed-article:16773074 | pubmed:author | pubmed-author:NaraharaHH | lld:pubmed |
| pubmed-article:16773074 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16773074 | pubmed:day | 19 | lld:pubmed |
| pubmed-article:16773074 | pubmed:volume | 94 | lld:pubmed |
| pubmed-article:16773074 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16773074 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16773074 | pubmed:pagination | 1803-8 | lld:pubmed |
| pubmed-article:16773074 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:16773074 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16773074 | pubmed:articleTitle | Phase I/II study of docetaxel and S-1 in patients with advanced gastric cancer. | lld:pubmed |
| pubmed-article:16773074 | pubmed:affiliation | Department of Gastroenterology, Saitama Cancer Centre, Ina-machi, Kitaadachi-gun, Japan. k-yamaguchi@cancer-c.pref.saitama.jp | lld:pubmed |
| pubmed-article:16773074 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16773074 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16773074 | pubmed:publicationType | Multicenter Study | lld:pubmed |
| pubmed-article:16773074 | pubmed:publicationType | Clinical Trial, Phase II | lld:pubmed |
| pubmed-article:16773074 | pubmed:publicationType | Clinical Trial, Phase I | lld:pubmed |
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