| pubmed-article:16756349 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16756349 | lifeskim:mentions | umls-concept:C0023418 | lld:lifeskim |
| pubmed-article:16756349 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:16756349 | lifeskim:mentions | umls-concept:C0910167 | lld:lifeskim |
| pubmed-article:16756349 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:16756349 | lifeskim:mentions | umls-concept:C0031715 | lld:lifeskim |
| pubmed-article:16756349 | lifeskim:mentions | umls-concept:C0282549 | lld:lifeskim |
| pubmed-article:16756349 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:16756349 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:16756349 | lifeskim:mentions | umls-concept:C0163305 | lld:lifeskim |
| pubmed-article:16756349 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:16756349 | pubmed:dateCreated | 2006-6-7 | lld:pubmed |
| pubmed-article:16756349 | pubmed:abstractText | Previously, we observed that luteolin effectively inhibited cell growth and induced apoptosis in HL-60 cells. In that study, we also explored the modulatory effects and molecular mechanisms of pyrrolidine dithiocarbamate (PDTC) on the cytotoxicity of luteolin to HL-60 cells. In this study, we found that PDTC was able to inhibit luteolin-induced cell apoptosis in a dose-dependent manner. When HL-60 cells were treated with PDTC for 0.5 h before 60 microM luteolin treatment, the DNA ladder disappeared. Moreover, flow cytometry showed that PDTC had dose dependently decreased the percentage of apoptotic HL-60 cells and had not interfered with luteolin's ability to change the mitochondrial membrane potential or its ability to trigger the release of cytochrome c to cytosol. Detection by Western blotting, however, did show that PDTC had interfered with luteolin's ability to cleave poly(ADP-ribose)polymerase and DNA fragmentation of factor-45. Three hours after the PDTC-pretreated HL-60 cells were treated with 60 microM luteolin, the product cleaved from Akt started to appear. Therefore, not only was PDTC able to stop the apoptosis of HL-60 cells treated with luteolin, it was also found to increase phosphorylation of Akt and caspase-9. These results suggest that in the luteolin-induced apoptotic pathway, phosphorylation of procaspase-9 by survival signals might play an important role in the ultimate fate of HL-60 cells. | lld:pubmed |
| pubmed-article:16756349 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16756349 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16756349 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16756349 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16756349 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16756349 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16756349 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16756349 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16756349 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16756349 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16756349 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16756349 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16756349 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16756349 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16756349 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16756349 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16756349 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16756349 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:16756349 | pubmed:issn | 0021-8561 | lld:pubmed |
| pubmed-article:16756349 | pubmed:author | pubmed-author:HoChi-TangCT | lld:pubmed |
| pubmed-article:16756349 | pubmed:author | pubmed-author:HuangYing-Tan... | lld:pubmed |
| pubmed-article:16756349 | pubmed:author | pubmed-author:PanMin-Hsiung... | lld:pubmed |
| pubmed-article:16756349 | pubmed:author | pubmed-author:HuangTzou-Chi... | lld:pubmed |
| pubmed-article:16756349 | pubmed:author | pubmed-author:LaiChing-ShuC... | lld:pubmed |
| pubmed-article:16756349 | pubmed:author | pubmed-author:ChengAn-ChinA... | lld:pubmed |
| pubmed-article:16756349 | pubmed:author | pubmed-author:LoChih-YuCY | lld:pubmed |
| pubmed-article:16756349 | pubmed:author | pubmed-author:KuoJen-MinJM | lld:pubmed |
| pubmed-article:16756349 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16756349 | pubmed:day | 14 | lld:pubmed |
| pubmed-article:16756349 | pubmed:volume | 54 | lld:pubmed |
| pubmed-article:16756349 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16756349 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16756349 | pubmed:pagination | 4215-21 | lld:pubmed |
| pubmed-article:16756349 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:16756349 | pubmed:meshHeading | pubmed-meshheading:16756349... | lld:pubmed |
| pubmed-article:16756349 | pubmed:meshHeading | pubmed-meshheading:16756349... | lld:pubmed |
| pubmed-article:16756349 | pubmed:meshHeading | pubmed-meshheading:16756349... | lld:pubmed |
| pubmed-article:16756349 | pubmed:meshHeading | pubmed-meshheading:16756349... | lld:pubmed |
| pubmed-article:16756349 | pubmed:meshHeading | pubmed-meshheading:16756349... | lld:pubmed |
| pubmed-article:16756349 | pubmed:meshHeading | pubmed-meshheading:16756349... | lld:pubmed |
| pubmed-article:16756349 | pubmed:meshHeading | pubmed-meshheading:16756349... | lld:pubmed |
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| pubmed-article:16756349 | pubmed:meshHeading | pubmed-meshheading:16756349... | lld:pubmed |
| pubmed-article:16756349 | pubmed:meshHeading | pubmed-meshheading:16756349... | lld:pubmed |
| pubmed-article:16756349 | pubmed:meshHeading | pubmed-meshheading:16756349... | lld:pubmed |
| pubmed-article:16756349 | pubmed:meshHeading | pubmed-meshheading:16756349... | lld:pubmed |
| pubmed-article:16756349 | pubmed:meshHeading | pubmed-meshheading:16756349... | lld:pubmed |
| pubmed-article:16756349 | pubmed:meshHeading | pubmed-meshheading:16756349... | lld:pubmed |
| pubmed-article:16756349 | pubmed:meshHeading | pubmed-meshheading:16756349... | lld:pubmed |
| pubmed-article:16756349 | pubmed:meshHeading | pubmed-meshheading:16756349... | lld:pubmed |
| pubmed-article:16756349 | pubmed:meshHeading | pubmed-meshheading:16756349... | lld:pubmed |
| pubmed-article:16756349 | pubmed:meshHeading | pubmed-meshheading:16756349... | lld:pubmed |
| pubmed-article:16756349 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16756349 | pubmed:articleTitle | Pyrrolidine dithiocarbamate inhibition of luteolin-induced apoptosis through up-regulated phosphorylation of Akt and caspase-9 in human leukemia HL-60 cells. | lld:pubmed |
| pubmed-article:16756349 | pubmed:affiliation | Department of Physical Therapy, Shu-Zen College of Medicine and Management, Kaohsiung County, Taiwan. | lld:pubmed |
| pubmed-article:16756349 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16756349 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
