| pubmed-article:16750386 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16750386 | lifeskim:mentions | umls-concept:C0007188 | lld:lifeskim |
| pubmed-article:16750386 | lifeskim:mentions | umls-concept:C0022023 | lld:lifeskim |
| pubmed-article:16750386 | lifeskim:mentions | umls-concept:C0439064 | lld:lifeskim |
| pubmed-article:16750386 | lifeskim:mentions | umls-concept:C1306673 | lld:lifeskim |
| pubmed-article:16750386 | lifeskim:mentions | umls-concept:C0037813 | lld:lifeskim |
| pubmed-article:16750386 | lifeskim:mentions | umls-concept:C1516801 | lld:lifeskim |
| pubmed-article:16750386 | lifeskim:mentions | umls-concept:C2347727 | lld:lifeskim |
| pubmed-article:16750386 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:16750386 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:16750386 | pubmed:dateCreated | 2006-7-31 | lld:pubmed |
| pubmed-article:16750386 | pubmed:abstractText | The application of multiple-stage ion-trap (IT) mass spectrometric methods for the structural characterization of cardiolipin (CL), a 1,3-bisphosphatidyl-sn-glycerol that consists of four fatty acyl chains and three glycerol backbones (designated as A, B, and central glycerol, respectively), as the sodiated adduct ions in the positive-ion mode was evaluated. Following collisionally activated dissociation (CAD), the [M - 2H + 3Na]+ ions of CL yield two prominent fragment ion pairs that consist of the phosphatidyl moieties attached to the 1'- and 3'-position of the central glycerol, respectively, resulting from the differential losses of the diacylglycerol moieties containing A and B glycerol, respectively. The results are consistent with those previously described for the [M - H]- and [M - 2H + Na]- ions in the negative-ion mode, thus permitting assignment of the two phosphatidyl moieties attached to the 1'- or 3'-position of the central glycerol. The identities of the fatty acyl substituents and their positions on the glycerol backbones (glycerol A and B) are deduced from further degradation of the above ion pairs that give the fragment ions reflecting the fatty acid substituents at the sn-1 (or sn-1') and sn-2 (or sn-2') positions. The ions that arise from losses of the fatty acid substituents at sn-1 and sn-1', respectively, are prominent, but the analogous ions from losses of the fatty acid substituents at sn-2 and sn-2', respectively, are of low abundance in the MS2 product-ion spectra. This feature further confirms the assignment of the positions of the fatty acid substituents. The similar IT multiple-stage mass spectrometric approaches including MS2 and MS3 for structural characterization of CL using its [M + Na]+ and the [M - H + 2Na]+ ions are also readily applicable. However, their uses for structural characterization are less desirable because formation of the [M + Na]+ and the [M - H + 2Na]+ ions for CL is not predictable. | lld:pubmed |
| pubmed-article:16750386 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16750386 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16750386 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16750386 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16750386 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16750386 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16750386 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16750386 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16750386 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16750386 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16750386 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16750386 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16750386 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16750386 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16750386 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16750386 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16750386 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16750386 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16750386 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16750386 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16750386 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16750386 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16750386 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16750386 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16750386 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16750386 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16750386 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16750386 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16750386 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16750386 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16750386 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16750386 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:16750386 | pubmed:issn | 1044-0305 | lld:pubmed |
| pubmed-article:16750386 | pubmed:author | pubmed-author:HsuFong-FuFF | lld:pubmed |
| pubmed-article:16750386 | pubmed:author | pubmed-author:TurkJohnJ | lld:pubmed |
| pubmed-article:16750386 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16750386 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:16750386 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16750386 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16750386 | pubmed:pagination | 1146-57 | lld:pubmed |
| pubmed-article:16750386 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
| pubmed-article:16750386 | pubmed:meshHeading | pubmed-meshheading:16750386... | lld:pubmed |
| pubmed-article:16750386 | pubmed:meshHeading | pubmed-meshheading:16750386... | lld:pubmed |
| pubmed-article:16750386 | pubmed:meshHeading | pubmed-meshheading:16750386... | lld:pubmed |
| pubmed-article:16750386 | pubmed:meshHeading | pubmed-meshheading:16750386... | lld:pubmed |
| pubmed-article:16750386 | pubmed:meshHeading | pubmed-meshheading:16750386... | lld:pubmed |
| pubmed-article:16750386 | pubmed:meshHeading | pubmed-meshheading:16750386... | lld:pubmed |
| pubmed-article:16750386 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16750386 | pubmed:articleTitle | Characterization of cardiolipin as the sodiated ions by positive-ion electrospray ionization with multiple stage quadrupole ion-trap mass spectrometry. | lld:pubmed |
| pubmed-article:16750386 | pubmed:affiliation | Mass Spectrometry Resource, Division of Endocrinology, Diabetes, Metabolism, and Lipid Research, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA. fhsu@im.wustl.edu | lld:pubmed |
| pubmed-article:16750386 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16750386 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16750386 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16750386 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16750386 | lld:pubmed |
