| pubmed-article:1673994 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1673994 | lifeskim:mentions | umls-concept:C0012984 | lld:lifeskim |
| pubmed-article:1673994 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:1673994 | lifeskim:mentions | umls-concept:C0007776 | lld:lifeskim |
| pubmed-article:1673994 | lifeskim:mentions | umls-concept:C0022655 | lld:lifeskim |
| pubmed-article:1673994 | lifeskim:mentions | umls-concept:C0001613 | lld:lifeskim |
| pubmed-article:1673994 | lifeskim:mentions | umls-concept:C0019151 | lld:lifeskim |
| pubmed-article:1673994 | lifeskim:mentions | umls-concept:C0001128 | lld:lifeskim |
| pubmed-article:1673994 | lifeskim:mentions | umls-concept:C1167622 | lld:lifeskim |
| pubmed-article:1673994 | lifeskim:mentions | umls-concept:C0205359 | lld:lifeskim |
| pubmed-article:1673994 | lifeskim:mentions | umls-concept:C0205191 | lld:lifeskim |
| pubmed-article:1673994 | lifeskim:mentions | umls-concept:C1515926 | lld:lifeskim |
| pubmed-article:1673994 | lifeskim:mentions | umls-concept:C0205812 | lld:lifeskim |
| pubmed-article:1673994 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:1673994 | pubmed:dateCreated | 1991-6-12 | lld:pubmed |
| pubmed-article:1673994 | pubmed:abstractText | Excitatory amino acid receptor binding parameters were investigated in a spontaneous dog model of chronic hepatic encephalopathy. L-[3H]Glutamate, (+)-[3H]-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-im ine maleate ([3H]MK-801), [3H]kainate, and alpha-[3H]-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid ([3H]AMPA) binding experiments were performed using crude cerebrocortical synaptosomal membrane preparations from dogs with congenital portosystemic encephalopathy (PSE) and control dogs. There was no change in the affinity or density of L-[3H]-glutamate or [3H]MK-801 binding sites in dogs with congenital PSE compared with control dogs. However, in the PSE dogs there was a significant reduction in the density of [3H]kainate binding sites compared with control dogs and abolition of the low-affinity [3H]AMPA binding site. The relative binding capacity of PSE synaptosomal membranes for [3H]kainate and [3H]AMPA was expressed as the ratio Bmax/KD. There was a significant inverse correlation between the Bmax/KD ratio for [3H]AMPA binding and the worst grade of encephalopathy experienced by each dog. These results suggest that there is a significant perturbation of cerebrocortical non-N-methyl-D-aspartate receptor binding in dogs with congenital PSE which may have relevance to the pathogenesis of hepatic encephalopathy. | lld:pubmed |
| pubmed-article:1673994 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1673994 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1673994 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1673994 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1673994 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1673994 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1673994 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1673994 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1673994 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1673994 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1673994 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1673994 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1673994 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:1673994 | pubmed:issn | 0022-3042 | lld:pubmed |
| pubmed-article:1673994 | pubmed:author | pubmed-author:JohnstonG AGA | lld:pubmed |
| pubmed-article:1673994 | pubmed:author | pubmed-author:DoddP RPR | lld:pubmed |
| pubmed-article:1673994 | pubmed:author | pubmed-author:WatsonW EWE | lld:pubmed |
| pubmed-article:1673994 | pubmed:author | pubmed-author:MaddisonJ EJE | lld:pubmed |
| pubmed-article:1673994 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1673994 | pubmed:volume | 56 | lld:pubmed |
| pubmed-article:1673994 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1673994 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1673994 | pubmed:pagination | 1881-8 | lld:pubmed |
| pubmed-article:1673994 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:1673994 | pubmed:meshHeading | pubmed-meshheading:1673994-... | lld:pubmed |
| pubmed-article:1673994 | pubmed:meshHeading | pubmed-meshheading:1673994-... | lld:pubmed |
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| pubmed-article:1673994 | pubmed:meshHeading | pubmed-meshheading:1673994-... | lld:pubmed |
| pubmed-article:1673994 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1673994 | pubmed:articleTitle | Alterations in cortical [3H]kainate and alpha-[3H]amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid binding in a spontaneous canine model of chronic hepatic encephalopathy. | lld:pubmed |
| pubmed-article:1673994 | pubmed:affiliation | Department of Pharmacology, University of Sydney, New South Wales, Australia. | lld:pubmed |
| pubmed-article:1673994 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1673994 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
