| pubmed-article:16716193 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16716193 | lifeskim:mentions | umls-concept:C0506994 | lld:lifeskim |
| pubmed-article:16716193 | lifeskim:mentions | umls-concept:C0205112 | lld:lifeskim |
| pubmed-article:16716193 | lifeskim:mentions | umls-concept:C0733983 | lld:lifeskim |
| pubmed-article:16716193 | lifeskim:mentions | umls-concept:C0205216 | lld:lifeskim |
| pubmed-article:16716193 | lifeskim:mentions | umls-concept:C2610947 | lld:lifeskim |
| pubmed-article:16716193 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:16716193 | pubmed:dateCreated | 2006-5-23 | lld:pubmed |
| pubmed-article:16716193 | pubmed:abstractText | Synaptotagmin-like protein (Slp) 2-a is a putative Rab27A/B-effector protein and is implicated in intracellular membrane transport. However, the precise tissue distribution of Slp2-a protein and its functions remain largely unknown. In this study we used a specific anti-Slp2-a antibody to investigate the tissue distribution of Slp2-a in mice and found that Slp2-a is most abundantly expressed in mouse stomach. Co-immunoprecipitation experiments indicated that Slp2-a interacts with Rab27A/B in vivo. We also discovered that Slp2-a and Rab27A/B are predominantly localized at the apical region of gastric-surface mucous cells, where mucus granules are accumulated. Analysis of Slp2-a mutant mice generated by homologous recombination showed a reduced number of mucus granules, a deficiency of granule docking with the apical plasma membrane in the gastric-surface mucous cells and reduction of mucus secretion by Slp2-a-deficient gastric primary cells. Based on these results, we propose that Slp2-a is part of the mucin secretory machinery in surface mucous cells of mouse stomach. | lld:pubmed |
| pubmed-article:16716193 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16716193 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16716193 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16716193 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16716193 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16716193 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16716193 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16716193 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16716193 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:16716193 | pubmed:issn | 1356-9597 | lld:pubmed |
| pubmed-article:16716193 | pubmed:author | pubmed-author:MikoshibaKats... | lld:pubmed |
| pubmed-article:16716193 | pubmed:author | pubmed-author:TanakaToruT | lld:pubmed |
| pubmed-article:16716193 | pubmed:author | pubmed-author:FukudaMitsuno... | lld:pubmed |
| pubmed-article:16716193 | pubmed:author | pubmed-author:ItoharaShigey... | lld:pubmed |
| pubmed-article:16716193 | pubmed:author | pubmed-author:TaniSatoruS | lld:pubmed |
| pubmed-article:16716193 | pubmed:author | pubmed-author:SaegusaChikaC | lld:pubmed |
| pubmed-article:16716193 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16716193 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:16716193 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16716193 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16716193 | pubmed:pagination | 623-31 | lld:pubmed |
| pubmed-article:16716193 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:16716193 | pubmed:meshHeading | pubmed-meshheading:16716193... | lld:pubmed |
| pubmed-article:16716193 | pubmed:meshHeading | pubmed-meshheading:16716193... | lld:pubmed |
| pubmed-article:16716193 | pubmed:meshHeading | pubmed-meshheading:16716193... | lld:pubmed |
| pubmed-article:16716193 | pubmed:meshHeading | pubmed-meshheading:16716193... | lld:pubmed |
| pubmed-article:16716193 | pubmed:meshHeading | pubmed-meshheading:16716193... | lld:pubmed |
| pubmed-article:16716193 | pubmed:meshHeading | pubmed-meshheading:16716193... | lld:pubmed |
| pubmed-article:16716193 | pubmed:meshHeading | pubmed-meshheading:16716193... | lld:pubmed |
| pubmed-article:16716193 | pubmed:meshHeading | pubmed-meshheading:16716193... | lld:pubmed |
| pubmed-article:16716193 | pubmed:meshHeading | pubmed-meshheading:16716193... | lld:pubmed |
| pubmed-article:16716193 | pubmed:meshHeading | pubmed-meshheading:16716193... | lld:pubmed |
| pubmed-article:16716193 | pubmed:meshHeading | pubmed-meshheading:16716193... | lld:pubmed |
| pubmed-article:16716193 | pubmed:meshHeading | pubmed-meshheading:16716193... | lld:pubmed |
| pubmed-article:16716193 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16716193 | pubmed:articleTitle | Decreased basal mucus secretion by Slp2-a-deficient gastric surface mucous cells. | lld:pubmed |
| pubmed-article:16716193 | pubmed:affiliation | Fukuda Initiative Research Unit, RIKEN (The Institute of Physical and Chemical Research), 2-1 Hirosawa, Wako, Saitama 351-0198, Japan. | lld:pubmed |
| pubmed-article:16716193 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16716193 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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