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pubmed-article:16683837pubmed:abstractTextHere we report the construction of fully addressable DNA-based molecular tweezers to actuate coupling reactions in a programmable fashion. Three tweezers, each bearing two coupling reactants, are self-assembled on a linear DNA track. A fourth tweezer floating freely in solution can be brought to any one of the tweezers and close them by the addition of a unique pair of "fuel" DNA strands. The coupling reactions happen when the tweezers are closed, and this can be controlled sequentially from one tweezer to another. A molecular device of this kind would not only enable programmable chemical reactions but also allow distance-dependent control of biomolecular interactions.lld:pubmed
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pubmed-article:16683837pubmed:authorpubmed-author:LiuYanYlld:pubmed
pubmed-article:16683837pubmed:authorpubmed-author:YanHaoHlld:pubmed
pubmed-article:16683837pubmed:authorpubmed-author:ChhabraRahulRlld:pubmed
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pubmed-article:16683837pubmed:articleTitleAddressable molecular tweezers for DNA-templated coupling reactions.lld:pubmed
pubmed-article:16683837pubmed:affiliationDepartment of Chemistry and Biochemistry and The Biodesign Institute, Arizona State University, Tempe, Arizona 85287, USA.lld:pubmed
pubmed-article:16683837pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:16683837pubmed:publicationTypeResearch Support, U.S. Gov't, Non-P.H.S.lld:pubmed
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