| pubmed-article:1668284 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1668284 | lifeskim:mentions | umls-concept:C0021051 | lld:lifeskim |
| pubmed-article:1668284 | lifeskim:mentions | umls-concept:C0080202 | lld:lifeskim |
| pubmed-article:1668284 | lifeskim:mentions | umls-concept:C2362651 | lld:lifeskim |
| pubmed-article:1668284 | lifeskim:mentions | umls-concept:C0034819 | lld:lifeskim |
| pubmed-article:1668284 | lifeskim:mentions | umls-concept:C0599283 | lld:lifeskim |
| pubmed-article:1668284 | lifeskim:mentions | umls-concept:C1704666 | lld:lifeskim |
| pubmed-article:1668284 | lifeskim:mentions | umls-concept:C1517892 | lld:lifeskim |
| pubmed-article:1668284 | lifeskim:mentions | umls-concept:C0205349 | lld:lifeskim |
| pubmed-article:1668284 | lifeskim:mentions | umls-concept:C0208973 | lld:lifeskim |
| pubmed-article:1668284 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:1668284 | pubmed:dateCreated | 1992-8-26 | lld:pubmed |
| pubmed-article:1668284 | pubmed:abstractText | The interdependence of blunted T cell proliferation induced by anti-CD3 monoclonal antibodies (mAb) and the preactivation of T lymphocytes (CD25+) in ESRD patients was investigated in this study. We focused on the density of IL-2 (CD25) receptors [IL-2R] on the lymphocyte surface rather than enumeration of IL-2R positive cells. The effect of exogenous IL-2 on these parameters was also tested. Blunted T lymphocyte proliferation induced by anti-CD3 mAb is only partially corrected by addition of exogenous IL-2 after 24 hrs. Freshly isolated uremic CD4 T cells show higher percentage of IL-2 positive cells and a higher IL-2R density on the cell surface compared to controls. However, after anti-CD3 mAb stimulation the number of IL-2R positive cells and IL-2R density in CD4 T subset was significantly lower than in samples from normal donors. Exogenous IL-2 had no influence on IL-2R expression on CD4 cells in uremic patients. On the other hand, following anti-CD3 mAb stimulation uremic CD8 cells reveal more IL-2R positive cells with higher IL-2R density than in controls. Moreover, exogenous IL-2 enhance IL-2R expression and density on uremic CD8 cells more than in controls. Our results suggest that the blunted T cell proliferation in ESRD patients might result from (a) preactivation of CD4 T cells, (b) diminished response of uremic CD4 T cells to IL-2, and (c) higher suppressor cells activity. | lld:pubmed |
| pubmed-article:1668284 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1668284 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1668284 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1668284 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1668284 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1668284 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1668284 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1668284 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1668284 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1668284 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1668284 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:1668284 | pubmed:issn | 0141-2760 | lld:pubmed |
| pubmed-article:1668284 | pubmed:author | pubmed-author:StachowskiJJ | lld:pubmed |
| pubmed-article:1668284 | pubmed:author | pubmed-author:BaldamusC ACA | lld:pubmed |
| pubmed-article:1668284 | pubmed:author | pubmed-author:BurrichterHH | lld:pubmed |
| pubmed-article:1668284 | pubmed:author | pubmed-author:PollokMM | lld:pubmed |
| pubmed-article:1668284 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1668284 | pubmed:volume | 34 | lld:pubmed |
| pubmed-article:1668284 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1668284 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1668284 | pubmed:pagination | 171-7 | lld:pubmed |
| pubmed-article:1668284 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:1668284 | pubmed:meshHeading | pubmed-meshheading:1668284-... | lld:pubmed |
| pubmed-article:1668284 | pubmed:meshHeading | pubmed-meshheading:1668284-... | lld:pubmed |
| pubmed-article:1668284 | pubmed:meshHeading | pubmed-meshheading:1668284-... | lld:pubmed |
| pubmed-article:1668284 | pubmed:meshHeading | pubmed-meshheading:1668284-... | lld:pubmed |
| pubmed-article:1668284 | pubmed:meshHeading | pubmed-meshheading:1668284-... | lld:pubmed |
| pubmed-article:1668284 | pubmed:meshHeading | pubmed-meshheading:1668284-... | lld:pubmed |
| pubmed-article:1668284 | pubmed:meshHeading | pubmed-meshheading:1668284-... | lld:pubmed |
| pubmed-article:1668284 | pubmed:meshHeading | pubmed-meshheading:1668284-... | lld:pubmed |
| pubmed-article:1668284 | pubmed:meshHeading | pubmed-meshheading:1668284-... | lld:pubmed |
| pubmed-article:1668284 | pubmed:meshHeading | pubmed-meshheading:1668284-... | lld:pubmed |
| pubmed-article:1668284 | pubmed:meshHeading | pubmed-meshheading:1668284-... | lld:pubmed |
| pubmed-article:1668284 | pubmed:meshHeading | pubmed-meshheading:1668284-... | lld:pubmed |
| pubmed-article:1668284 | pubmed:meshHeading | pubmed-meshheading:1668284-... | lld:pubmed |
| pubmed-article:1668284 | pubmed:meshHeading | pubmed-meshheading:1668284-... | lld:pubmed |
| pubmed-article:1668284 | pubmed:meshHeading | pubmed-meshheading:1668284-... | lld:pubmed |
| pubmed-article:1668284 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1668284 | pubmed:articleTitle | Immunodeficiency in ESRD-patients is linked to altered IL-2 receptor density on T cell subsets. | lld:pubmed |
| pubmed-article:1668284 | pubmed:affiliation | Department of Nephrology, University of Cologne, Germany. | lld:pubmed |
| pubmed-article:1668284 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1668284 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
