| pubmed-article:16647250 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16647250 | lifeskim:mentions | umls-concept:C0020179 | lld:lifeskim |
| pubmed-article:16647250 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:16647250 | lifeskim:mentions | umls-concept:C0056077 | lld:lifeskim |
| pubmed-article:16647250 | lifeskim:mentions | umls-concept:C0178602 | lld:lifeskim |
| pubmed-article:16647250 | lifeskim:mentions | umls-concept:C0524527 | lld:lifeskim |
| pubmed-article:16647250 | lifeskim:mentions | umls-concept:C1707887 | lld:lifeskim |
| pubmed-article:16647250 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:16647250 | pubmed:dateCreated | 2006-6-19 | lld:pubmed |
| pubmed-article:16647250 | pubmed:abstractText | There is substantial evidence that a bioenergetic defect may play a role in the pathogenesis of Huntington's Disease (HD). A potential therapy for remediating defective energy metabolism is the mitochondrial cofactor, coenzyme Q10 (CoQ10). We have reported that CoQ10 is neuroprotective in the R6/2 transgenic mouse model of HD. Based upon the encouraging results of the CARE-HD trial and recent evidence that high-dose CoQ10 slows the progressive functional decline in Parkinson's disease, we performed a dose ranging study administering high levels of CoQ10 from two commercial sources in R6/2 mice to determine enhanced efficacy. High dose CoQ10 significantly extended survival in R6/2 mice, the degree of which was dose- and source-dependent. CoQ10 resulted in a marked improvement in motor performance and grip strength, with a reduction in weight loss, brain atrophy, and huntingtin inclusions in treated R6/2 mice. Brain levels of CoQ10 and CoQ9 were significantly lower in R6/2 mice, in comparison to wild type littermate control mice. Oral administration of CoQ10 elevated CoQ10 plasma levels and significantly increased brain levels of CoQ9, CoQ10, and ATP in R6/2 mice, while reducing 8-hydroxy-2-deoxyguanosine concentrations, a marker of oxidative damage. We demonstrate that high-dose administration of CoQ10 exerts a greater therapeutic benefit in a dose dependent manner in R6/2 mice than previously reported and suggest that clinical trials using high dose CoQ10 in HD patients are warranted. | lld:pubmed |
| pubmed-article:16647250 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16647250 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16647250 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16647250 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16647250 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16647250 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16647250 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16647250 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16647250 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16647250 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16647250 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16647250 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16647250 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16647250 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16647250 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16647250 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16647250 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16647250 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16647250 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:16647250 | pubmed:issn | 0006-3002 | lld:pubmed |
| pubmed-article:16647250 | pubmed:author | pubmed-author:StackEdward... | lld:pubmed |
| pubmed-article:16647250 | pubmed:author | pubmed-author:MatsonSamanth... | lld:pubmed |
| pubmed-article:16647250 | pubmed:author | pubmed-author:MatsonWayne... | lld:pubmed |
| pubmed-article:16647250 | pubmed:author | pubmed-author:FerranteRober... | lld:pubmed |
| pubmed-article:16647250 | pubmed:author | pubmed-author:JekoWW | lld:pubmed |
| pubmed-article:16647250 | pubmed:author | pubmed-author:SmithKaren... | lld:pubmed |
| pubmed-article:16647250 | pubmed:author | pubmed-author:CormierKerryK | lld:pubmed |
| pubmed-article:16647250 | pubmed:author | pubmed-author:Del... | lld:pubmed |
| pubmed-article:16647250 | pubmed:author | pubmed-author:HagertySean... | lld:pubmed |
| pubmed-article:16647250 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16647250 | pubmed:volume | 1762 | lld:pubmed |
| pubmed-article:16647250 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16647250 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16647250 | pubmed:pagination | 616-26 | lld:pubmed |
| pubmed-article:16647250 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:16647250 | pubmed:meshHeading | pubmed-meshheading:16647250... | lld:pubmed |
| pubmed-article:16647250 | pubmed:meshHeading | pubmed-meshheading:16647250... | lld:pubmed |
| pubmed-article:16647250 | pubmed:meshHeading | pubmed-meshheading:16647250... | lld:pubmed |
| pubmed-article:16647250 | pubmed:meshHeading | pubmed-meshheading:16647250... | lld:pubmed |
| pubmed-article:16647250 | pubmed:meshHeading | pubmed-meshheading:16647250... | lld:pubmed |
| pubmed-article:16647250 | pubmed:meshHeading | pubmed-meshheading:16647250... | lld:pubmed |
| pubmed-article:16647250 | pubmed:meshHeading | pubmed-meshheading:16647250... | lld:pubmed |
| pubmed-article:16647250 | pubmed:meshHeading | pubmed-meshheading:16647250... | lld:pubmed |
| pubmed-article:16647250 | pubmed:meshHeading | pubmed-meshheading:16647250... | lld:pubmed |
| pubmed-article:16647250 | pubmed:meshHeading | pubmed-meshheading:16647250... | lld:pubmed |
| pubmed-article:16647250 | pubmed:meshHeading | pubmed-meshheading:16647250... | lld:pubmed |
| pubmed-article:16647250 | pubmed:meshHeading | pubmed-meshheading:16647250... | lld:pubmed |
| pubmed-article:16647250 | pubmed:meshHeading | pubmed-meshheading:16647250... | lld:pubmed |
| pubmed-article:16647250 | pubmed:meshHeading | pubmed-meshheading:16647250... | lld:pubmed |
| pubmed-article:16647250 | pubmed:meshHeading | pubmed-meshheading:16647250... | lld:pubmed |
| pubmed-article:16647250 | pubmed:meshHeading | pubmed-meshheading:16647250... | lld:pubmed |
| pubmed-article:16647250 | pubmed:meshHeading | pubmed-meshheading:16647250... | lld:pubmed |
| pubmed-article:16647250 | pubmed:meshHeading | pubmed-meshheading:16647250... | lld:pubmed |
| pubmed-article:16647250 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16647250 | pubmed:articleTitle | Dose ranging and efficacy study of high-dose coenzyme Q10 formulations in Huntington's disease mice. | lld:pubmed |
| pubmed-article:16647250 | pubmed:affiliation | Geriatric Research Education and Clinical Center, Bedford VA Medical Center, Bedford 01730, and Neurology Department, Boston University School of Medicine, MA 02180, USA. | lld:pubmed |
| pubmed-article:16647250 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16647250 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:16647250 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16647250 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16647250 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16647250 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16647250 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16647250 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16647250 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16647250 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16647250 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16647250 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16647250 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16647250 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16647250 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16647250 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16647250 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16647250 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16647250 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16647250 | lld:pubmed |
