| pubmed-article:16630839 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16630839 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
| pubmed-article:16630839 | lifeskim:mentions | umls-concept:C0019564 | lld:lifeskim |
| pubmed-article:16630839 | lifeskim:mentions | umls-concept:C0011305 | lld:lifeskim |
| pubmed-article:16630839 | lifeskim:mentions | umls-concept:C0442038 | lld:lifeskim |
| pubmed-article:16630839 | lifeskim:mentions | umls-concept:C1413038 | lld:lifeskim |
| pubmed-article:16630839 | lifeskim:mentions | umls-concept:C0205315 | lld:lifeskim |
| pubmed-article:16630839 | lifeskim:mentions | umls-concept:C0871161 | lld:lifeskim |
| pubmed-article:16630839 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:16630839 | pubmed:dateCreated | 2006-4-24 | lld:pubmed |
| pubmed-article:16630839 | pubmed:abstractText | Although radial oblique dendrites are a major synaptic input site in CA1 pyramidal neurons, little is known about their integrative properties. We have used multisite two-photon glutamate uncaging to deliver different spatiotemporal input patterns to single branches while simultaneously recording the uncaging-evoked excitatory postsynaptic potentials and local Ca2+ signals. Asynchronous input patterns sum linearly in spite of the spatial clustering and produce Ca2+ signals that are mediated by NMDA receptors (NMDARs). Appropriately timed and sized input patterns ( approximately 20 inputs within approximately 6 ms) produce a supralinear summation due to the initiation of a dendritic spike. The Ca2+ signals associated with synchronous input were larger and mediated by influx through both NMDARs and voltage-gated Ca2+ channels (VGCCs). The oblique spike is a fast Na+ spike whose duration is shaped by the coincident activation of NMDAR, VGCCs, and transient K+ currents. Our results suggest that individual branches can function as single integrative compartments. | lld:pubmed |
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| pubmed-article:16630839 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:16630839 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16630839 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16630839 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:16630839 | pubmed:issn | 0896-6273 | lld:pubmed |
| pubmed-article:16630839 | pubmed:author | pubmed-author:MageeJeffrey... | lld:pubmed |
| pubmed-article:16630839 | pubmed:author | pubmed-author:LosonczyAttil... | lld:pubmed |
| pubmed-article:16630839 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16630839 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:16630839 | pubmed:volume | 50 | lld:pubmed |
| pubmed-article:16630839 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16630839 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16630839 | pubmed:pagination | 291-307 | lld:pubmed |
| pubmed-article:16630839 | pubmed:dateRevised | 2010-9-17 | lld:pubmed |
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| pubmed-article:16630839 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16630839 | pubmed:articleTitle | Integrative properties of radial oblique dendrites in hippocampal CA1 pyramidal neurons. | lld:pubmed |
| pubmed-article:16630839 | pubmed:affiliation | Neuroscience Center, Louisiana State University Health Science Center, New Orleans, Louisiana 70112, USA. aloson@lsuhsc.edu | lld:pubmed |
| pubmed-article:16630839 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16630839 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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