| pubmed-article:16601244 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16601244 | lifeskim:mentions | umls-concept:C0023434 | lld:lifeskim |
| pubmed-article:16601244 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:16601244 | lifeskim:mentions | umls-concept:C0246976 | lld:lifeskim |
| pubmed-article:16601244 | lifeskim:mentions | umls-concept:C2826293 | lld:lifeskim |
| pubmed-article:16601244 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:16601244 | pubmed:dateCreated | 2006-7-24 | lld:pubmed |
| pubmed-article:16601244 | pubmed:abstractText | The clinical course of B-cell chronic lymphocytic leukemia (B-CLL) is variable, and novel biologic parameters need to be added to the clinical staging systems to predict an indolent or aggressive outcome. We investigated the 70-kDa zeta-associated protein (ZAP-70), CD38, soluble CD23 (sCD23), and cytogenetics in 289 patients with B-CLL. Both a shorter progression-free survival (PFS) and overall survival (OS) were observed in ZAP-70(+) (P < .001), in CD38(+) (P < .001) and in sCD23(+) patients (P < .001 and P = .013, respectively). ZAP-70(+)CD38(+) or ZAP-70(+) patients with an unmutated IgV(H) status showed both a shorter PFS (P < .001) and OS (P < .001 and P < .001, respectively) as compared with ZAP-70(-)/CD38(-) or ZAP-70(-) patients with mutated IgV(H) genes. Discordant patients showed an intermediate outcome. Note, ZAP-70(+) patients even if CD38(-) or mutated showed a shorter PFS, whereas ZAP-70(-) patients even if CD38(+) or unmutated had a longer PFS. Furthermore, ZAP-70 positivity was associated with a shorter PFS both within normal karyotype (P < .001) and within the poor-risk cytogenetic subset (P = .02). The predictive value of ZAP-70 expression was confirmed in multivariate analysis. Thus, ZAP-70 protein determined by flow cytometry improves the prognostic significance of cytogenetics and appears to be a better predictor of outcomes than IgV(H) gene mutational status. On this line, we recommend and are also interested in conducting a prospective randomized trial of early intervention versus observation for ZAP-70(+) patients. | lld:pubmed |
| pubmed-article:16601244 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16601244 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16601244 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:16601244 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16601244 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16601244 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16601244 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:16601244 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:16601244 | pubmed:author | pubmed-author:Lo... | lld:pubmed |
| pubmed-article:16601244 | pubmed:author | pubmed-author:GatteiValterV | lld:pubmed |
| pubmed-article:16601244 | pubmed:author | pubmed-author:AmadoriSergio... | lld:pubmed |
| pubmed-article:16601244 | pubmed:author | pubmed-author:DeganMassimoM | lld:pubmed |
| pubmed-article:16601244 | pubmed:author | pubmed-author:VendittiAdria... | lld:pubmed |
| pubmed-article:16601244 | pubmed:author | pubmed-author:BuccisanoFran... | lld:pubmed |
| pubmed-article:16601244 | pubmed:author | pubmed-author:Del... | lld:pubmed |
| pubmed-article:16601244 | pubmed:author | pubmed-author:MaurilloLucaL | lld:pubmed |
| pubmed-article:16601244 | pubmed:author | pubmed-author:PanettaPaolaP | lld:pubmed |
| pubmed-article:16601244 | pubmed:author | pubmed-author:CantonettiMar... | lld:pubmed |
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| pubmed-article:16601244 | pubmed:author | pubmed-author:MazzoneCarlaC | lld:pubmed |
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| pubmed-article:16601244 | pubmed:author | pubmed-author:NiscolaPasqua... | lld:pubmed |
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| pubmed-article:16601244 | pubmed:author | pubmed-author:MariniRitaR | lld:pubmed |
| pubmed-article:16601244 | pubmed:author | pubmed-author:ConsalvoMaria... | lld:pubmed |
| pubmed-article:16601244 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16601244 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:16601244 | pubmed:volume | 108 | lld:pubmed |
| pubmed-article:16601244 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16601244 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16601244 | pubmed:pagination | 853-61 | lld:pubmed |
| pubmed-article:16601244 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:16601244 | pubmed:meshHeading | pubmed-meshheading:16601244... | lld:pubmed |
| pubmed-article:16601244 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16601244 | pubmed:articleTitle | Clinical significance of ZAP-70 protein expression in B-cell chronic lymphocytic leukemia. | lld:pubmed |
| pubmed-article:16601244 | pubmed:affiliation | Cattedra di Ematologia, Università Tor Vergata, Ospedale S Eugenio, Via Fiume Giallo, 430 MA, 00144 Roma, Rome, Italy. | lld:pubmed |
| pubmed-article:16601244 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16601244 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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