| pubmed-article:1656038 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1656038 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:1656038 | lifeskim:mentions | umls-concept:C0005821 | lld:lifeskim |
| pubmed-article:1656038 | lifeskim:mentions | umls-concept:C0037473 | lld:lifeskim |
| pubmed-article:1656038 | lifeskim:mentions | umls-concept:C0085580 | lld:lifeskim |
| pubmed-article:1656038 | lifeskim:mentions | umls-concept:C0439857 | lld:lifeskim |
| pubmed-article:1656038 | lifeskim:mentions | umls-concept:C0678640 | lld:lifeskim |
| pubmed-article:1656038 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:1656038 | pubmed:dateCreated | 1991-11-4 | lld:pubmed |
| pubmed-article:1656038 | pubmed:abstractText | The sodium dependence of recovery of cytoplasmic pH (pHi) after an acid load was studied in platelets from 15 patients with untreated essential hypertension (mean arterial pressure 117 +/- 2.3 mmHg, mean +/- SE) and in 15 normotensive controls (mean arterial pressure 90 +/- 2.2 mmHg). Proton flux was measured in gel-filtered platelets loaded with pH sensitive fluorescent indicator. Sodium dependent proton efflux was prevented by 5 (N,N hexamethylene) amiloride, a potent inhibitor of sodium-proton exchange. The relationship between initial rate of proton efflux and extracellular sodium concentration obeyed Michaelis-Menten kinetics. The maximum initial rate of proton efflux was similar in hypertensive and normotensive subjects (1.93 +/- 0.35 mmol H+1/sec, mean +/- SE, and 1.88 +/- 0.26 mmol H+l/sec respectively). The Michaelis-Menten constant (the sodium concentration at which the initial rate of proton efflux is half maximal) was also similar in the two groups: 75.7 +/- 13.9 mmol/l and 8.15 +/- 10.6 mmol/l respectively. There was no significant correlation between either of these parameters and arterial blood pressure. | lld:pubmed |
| pubmed-article:1656038 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1656038 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1656038 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1656038 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1656038 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1656038 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1656038 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1656038 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1656038 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1656038 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:1656038 | pubmed:issn | 0950-9240 | lld:pubmed |
| pubmed-article:1656038 | pubmed:author | pubmed-author:BenjaminNN | lld:pubmed |
| pubmed-article:1656038 | pubmed:author | pubmed-author:ToddS DSD | lld:pubmed |
| pubmed-article:1656038 | pubmed:author | pubmed-author:RitterJ MJM | lld:pubmed |
| pubmed-article:1656038 | pubmed:author | pubmed-author:DoktorH SHS | lld:pubmed |
| pubmed-article:1656038 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1656038 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:1656038 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1656038 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1656038 | pubmed:pagination | 161-5 | lld:pubmed |
| pubmed-article:1656038 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:1656038 | pubmed:meshHeading | pubmed-meshheading:1656038-... | lld:pubmed |
| pubmed-article:1656038 | pubmed:meshHeading | pubmed-meshheading:1656038-... | lld:pubmed |
| pubmed-article:1656038 | pubmed:meshHeading | pubmed-meshheading:1656038-... | lld:pubmed |
| pubmed-article:1656038 | pubmed:meshHeading | pubmed-meshheading:1656038-... | lld:pubmed |
| pubmed-article:1656038 | pubmed:meshHeading | pubmed-meshheading:1656038-... | lld:pubmed |
| pubmed-article:1656038 | pubmed:meshHeading | pubmed-meshheading:1656038-... | lld:pubmed |
| pubmed-article:1656038 | pubmed:meshHeading | pubmed-meshheading:1656038-... | lld:pubmed |
| pubmed-article:1656038 | pubmed:meshHeading | pubmed-meshheading:1656038-... | lld:pubmed |
| pubmed-article:1656038 | pubmed:meshHeading | pubmed-meshheading:1656038-... | lld:pubmed |
| pubmed-article:1656038 | pubmed:meshHeading | pubmed-meshheading:1656038-... | lld:pubmed |
| pubmed-article:1656038 | pubmed:meshHeading | pubmed-meshheading:1656038-... | lld:pubmed |
| pubmed-article:1656038 | pubmed:meshHeading | pubmed-meshheading:1656038-... | lld:pubmed |
| pubmed-article:1656038 | pubmed:meshHeading | pubmed-meshheading:1656038-... | lld:pubmed |
| pubmed-article:1656038 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1656038 | pubmed:articleTitle | Sodium dependence of sodium-proton exchange in platelets from patients with essential hypertension. | lld:pubmed |
| pubmed-article:1656038 | pubmed:affiliation | Department of Clinical Pharmacology, United Medical School, Guy's Hospital, London, UK. | lld:pubmed |
| pubmed-article:1656038 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1656038 | lld:pubmed |
