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| pubmed-article:1654564 | lifeskim:mentions | umls-concept:C0019351 | lld:lifeskim |
| pubmed-article:1654564 | lifeskim:mentions | umls-concept:C1510411 | lld:lifeskim |
| pubmed-article:1654564 | lifeskim:mentions | umls-concept:C0205282 | lld:lifeskim |
| pubmed-article:1654564 | lifeskim:mentions | umls-concept:C0035547 | lld:lifeskim |
| pubmed-article:1654564 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:1654564 | lifeskim:mentions | umls-concept:C1514562 | lld:lifeskim |
| pubmed-article:1654564 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:1654564 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:1654564 | lifeskim:mentions | umls-concept:C1711351 | lld:lifeskim |
| pubmed-article:1654564 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:1654564 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:1654564 | pubmed:issue | 18 | lld:pubmed |
| pubmed-article:1654564 | pubmed:dateCreated | 1991-10-21 | lld:pubmed |
| pubmed-article:1654564 | pubmed:abstractText | The 1.3-kilobase (kb) Pst I DNA fragment C (Pst I-C) of herpes simplex virus type 2 (HSV-2) morphological transforming region III (mtrIII; map unit 0.562-0.570) encodes part of the N-terminal half of the large subunit of ribonucleotide reductase (RR1; amino acid residues 71-502) and induces the neoplastic transformation of immortalized cell lines. To assess directly the role of these RR1 protein sequences in cell transformation, the Pst I-C fragment was cloned in an expression vector (p91023) containing an adenovirus-simian virus 40 promoter-enhancer to generate recombinant plasmid p9-C. Expression of a protein domain (approximately 65 kDa) was observed in p9-C-transfected COS-7 and Rat2 cells but not in those transfected with plasmid pHC-14 (Pst I-C in a promoterless vector). In Rat2 cells, p9-C induced highly transformed foci at an elevated frequency compared with that of pHC-14. Introduction of translation termination (TAG) condons within the RR1 coding sequence and within all three reading frames inactivated RR1 protein expression from p9-C and reduced its transforming activity to the level seen with the standard pHC-14 construct. Wild-type p9-C specified a protein kinase capable of autophosphorylation. Computer-assisted analysis further revealed significant similarity between regions of mtrIII-specific RR1 and amino acid patterns conserved within the proinsulin precursor family and DNA transposition proteins. These results identify a distinct domain of the HSV-2 RR1 protein involved in the induction of enhanced malignant transformation. In addition, the data indicate that the mtrIII DNA itself can induce basal-level transformation in the absence of protein expression. | lld:pubmed |
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| pubmed-article:1654564 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:1654564 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1654564 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1654564 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:1654564 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:1654564 | pubmed:author | pubmed-author:JariwallaR... | lld:pubmed |
| pubmed-article:1654564 | pubmed:author | pubmed-author:ROYJ BJB | lld:pubmed |
| pubmed-article:1654564 | pubmed:author | pubmed-author:JurkaJJ | lld:pubmed |
| pubmed-article:1654564 | pubmed:author | pubmed-author:Milosavljevic... | lld:pubmed |
| pubmed-article:1654564 | pubmed:author | pubmed-author:McWeeneyDD | lld:pubmed |
| pubmed-article:1654564 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1654564 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:1654564 | pubmed:volume | 88 | lld:pubmed |
| pubmed-article:1654564 | pubmed:geneSymbol | mtrIII | lld:pubmed |
| pubmed-article:1654564 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1654564 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1654564 | pubmed:pagination | 8257-61 | lld:pubmed |
| pubmed-article:1654564 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:1654564 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1654564 | pubmed:articleTitle | Enhanced malignant transformation induced by expression of a distinct protein domain of ribonucleotide reductase large subunit from herpes simplex virus type 2. | lld:pubmed |
| pubmed-article:1654564 | pubmed:affiliation | Viral Carcinogenesis Laboratories, Linus Pauling Institute of Science and Medicine, Palo Alto, CA 94306. | lld:pubmed |
| pubmed-article:1654564 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1654564 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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