| pubmed-article:16542149 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16542149 | lifeskim:mentions | umls-concept:C1332409 | lld:lifeskim |
| pubmed-article:16542149 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:16542149 | lifeskim:mentions | umls-concept:C0080347 | lld:lifeskim |
| pubmed-article:16542149 | lifeskim:mentions | umls-concept:C0076922 | lld:lifeskim |
| pubmed-article:16542149 | lifeskim:mentions | umls-concept:C1711351 | lld:lifeskim |
| pubmed-article:16542149 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:16542149 | pubmed:dateCreated | 2006-3-17 | lld:pubmed |
| pubmed-article:16542149 | pubmed:abstractText | The human gene BDP1, localized on chromosome 5q13 in close proximity to the spinal muscular atrophy determining gene SMN, encodes a large protein consisting of 2254 amino acids (aa). In the first third of the gene, the subunit of the RNA polymerase III (Pol III) transcription factor complex (TFIIIB alpha/beta) is encoded. To further characterize the function of BDP1, we carried out a yeast two-hybrid screen using various parts of BDP1. With the clone BDP1-(1-640) we identified a novel interaction partner, ZNF297B. The ZNF297B gene is localized on chromosome 9q24 and encodes a zinc finger protein of 467 aa possessing the typical structure of a transcription factor. The interaction found in yeast was confirmed by co-immunoprecipitation and refined to the N-terminal region of ZNF297B-(1-127) containing the BTB/POZ domain and the N-terminal end of BDP1-(1-299). The ZNF297B transcript is 5.7 kb in length and ubiquitously expressed, with highest levels found in muscles. Immunofluorescence staining revealed a speckled pattern in the nuclei of HEK293 cells. Due to the essential role of BDP1 in Pol III transcription, we propose that ZNF297B may also regulate these transcriptional pathways. | lld:pubmed |
| pubmed-article:16542149 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16542149 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16542149 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16542149 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16542149 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16542149 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16542149 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16542149 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16542149 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16542149 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16542149 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16542149 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:16542149 | pubmed:issn | 1431-6730 | lld:pubmed |
| pubmed-article:16542149 | pubmed:author | pubmed-author:ShuliakL PLP | lld:pubmed |
| pubmed-article:16542149 | pubmed:author | pubmed-author:WirthBrunhild... | lld:pubmed |
| pubmed-article:16542149 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16542149 | pubmed:volume | 387 | lld:pubmed |
| pubmed-article:16542149 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16542149 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16542149 | pubmed:pagination | 277-84 | lld:pubmed |
| pubmed-article:16542149 | pubmed:dateRevised | 2007-5-17 | lld:pubmed |
| pubmed-article:16542149 | pubmed:meshHeading | pubmed-meshheading:16542149... | lld:pubmed |
| pubmed-article:16542149 | pubmed:meshHeading | pubmed-meshheading:16542149... | lld:pubmed |
| pubmed-article:16542149 | pubmed:meshHeading | pubmed-meshheading:16542149... | lld:pubmed |
| pubmed-article:16542149 | pubmed:meshHeading | pubmed-meshheading:16542149... | lld:pubmed |
| pubmed-article:16542149 | pubmed:meshHeading | pubmed-meshheading:16542149... | lld:pubmed |
| pubmed-article:16542149 | pubmed:meshHeading | pubmed-meshheading:16542149... | lld:pubmed |
| pubmed-article:16542149 | pubmed:meshHeading | pubmed-meshheading:16542149... | lld:pubmed |
| pubmed-article:16542149 | pubmed:meshHeading | pubmed-meshheading:16542149... | lld:pubmed |
| pubmed-article:16542149 | pubmed:meshHeading | pubmed-meshheading:16542149... | lld:pubmed |
| pubmed-article:16542149 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16542149 | pubmed:articleTitle | The zinc finger protein ZNF297B interacts with BDP1, a subunit of TFIIIB. | lld:pubmed |
| pubmed-article:16542149 | pubmed:affiliation | Institute of Human Genetics, University of Cologne, D-50674 Cologne, Germany. | lld:pubmed |
| pubmed-article:16542149 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16542149 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:23099 | entrezgene:pubmed | pubmed-article:16542149 | lld:entrezgene |
| entrez-gene:55814 | entrezgene:pubmed | pubmed-article:16542149 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:16542149 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16542149 | lld:pubmed |
