| pubmed-article:16540370 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16540370 | lifeskim:mentions | umls-concept:C0033085 | lld:lifeskim |
| pubmed-article:16540370 | lifeskim:mentions | umls-concept:C0018787 | lld:lifeskim |
| pubmed-article:16540370 | lifeskim:mentions | umls-concept:C0027061 | lld:lifeskim |
| pubmed-article:16540370 | lifeskim:mentions | umls-concept:C1522564 | lld:lifeskim |
| pubmed-article:16540370 | lifeskim:mentions | umls-concept:C0178719 | lld:lifeskim |
| pubmed-article:16540370 | lifeskim:mentions | umls-concept:C0018810 | lld:lifeskim |
| pubmed-article:16540370 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:16540370 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:16540370 | lifeskim:mentions | umls-concept:C0205251 | lld:lifeskim |
| pubmed-article:16540370 | lifeskim:mentions | umls-concept:C0597484 | lld:lifeskim |
| pubmed-article:16540370 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:16540370 | pubmed:dateCreated | 2006-10-30 | lld:pubmed |
| pubmed-article:16540370 | pubmed:abstractText | We investigated the hypothesis that increased intracellular [Na+]i in heart failure contributes to preservation of SR Ca2+ load which may become particularly evident at slow heart rates. [Na+]i in SBFI-loaded myocytes from rabbits with pacing-induced heart failure (PHF) was significantly higher at each frequency as compared to Sham-operated animals. Furthermore, PHF rabbits demonstrated reduced SR Ca2+-ATPase protein levels (-37%, p < 0.04) but unchanged Na+/Ca2+ exchanger protein levels. At 0.25 Hz, isometric force was similar in cardiac trabeculae from PHF rabbits as compared to control (PHF, 3.6+/-1.3; Sham, 4.4+/-0.6 mN/mm2). Rapid cooling contractures (RCCs) were unchanged indicating preserved SR Ca2+ load at this frequency. In Sham, isometric twitch force increased with rising frequencies to 29.0+/-2.8 mN/mm2 at 3.0 Hz (p < 0.05) as compared to 0.25 Hz. RCCs showed a parallel increase by 186+/-47% (p < 0.01). In PHF, frequency-dependent increase in force (15.8+/-4.7 mN/mm2 at 3.0 Hz) and RCCs (increase by 70+/-40%) were significantly blunted. Thus, in PHF in rabbits SR Ca2+ load is preserved at low frequencies despite decreased SR Ca2+-ATPase expression. This may result from [Na+]i-dependent changes in Na+/Ca2+ exchanger activity. | lld:pubmed |
| pubmed-article:16540370 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16540370 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16540370 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16540370 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16540370 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16540370 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16540370 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16540370 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:16540370 | pubmed:issn | 1388-9842 | lld:pubmed |
| pubmed-article:16540370 | pubmed:author | pubmed-author:ZeitzOliverO | lld:pubmed |
| pubmed-article:16540370 | pubmed:author | pubmed-author:HasenfussGerd... | lld:pubmed |
| pubmed-article:16540370 | pubmed:author | pubmed-author:MaierLars SLS | lld:pubmed |
| pubmed-article:16540370 | pubmed:author | pubmed-author:SchmidtAlbrec... | lld:pubmed |
| pubmed-article:16540370 | pubmed:author | pubmed-author:Van... | lld:pubmed |
| pubmed-article:16540370 | pubmed:author | pubmed-author:SchillingerWo... | lld:pubmed |
| pubmed-article:16540370 | pubmed:author | pubmed-author:TeucherNilsN | lld:pubmed |
| pubmed-article:16540370 | pubmed:author | pubmed-author:NebendahlKlau... | lld:pubmed |
| pubmed-article:16540370 | pubmed:author | pubmed-author:KohlhaasMicha... | lld:pubmed |
| pubmed-article:16540370 | pubmed:author | pubmed-author:ChristiansCla... | lld:pubmed |
| pubmed-article:16540370 | pubmed:author | pubmed-author:SossallaSamue... | lld:pubmed |
| pubmed-article:16540370 | pubmed:author | pubmed-author:SchunckOrtwin... | lld:pubmed |
| pubmed-article:16540370 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16540370 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:16540370 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16540370 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16540370 | pubmed:pagination | 673-80 | lld:pubmed |
| pubmed-article:16540370 | pubmed:dateRevised | 2011-6-8 | lld:pubmed |
| pubmed-article:16540370 | pubmed:meshHeading | pubmed-meshheading:16540370... | lld:pubmed |
| pubmed-article:16540370 | pubmed:meshHeading | pubmed-meshheading:16540370... | lld:pubmed |
| pubmed-article:16540370 | pubmed:meshHeading | pubmed-meshheading:16540370... | lld:pubmed |
| pubmed-article:16540370 | pubmed:meshHeading | pubmed-meshheading:16540370... | lld:pubmed |
| pubmed-article:16540370 | pubmed:meshHeading | pubmed-meshheading:16540370... | lld:pubmed |
| pubmed-article:16540370 | pubmed:meshHeading | pubmed-meshheading:16540370... | lld:pubmed |
| pubmed-article:16540370 | pubmed:meshHeading | pubmed-meshheading:16540370... | lld:pubmed |
| pubmed-article:16540370 | pubmed:meshHeading | pubmed-meshheading:16540370... | lld:pubmed |
| pubmed-article:16540370 | pubmed:meshHeading | pubmed-meshheading:16540370... | lld:pubmed |
| pubmed-article:16540370 | pubmed:meshHeading | pubmed-meshheading:16540370... | lld:pubmed |
| pubmed-article:16540370 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16540370 | pubmed:articleTitle | High intracellular Na+ preserves myocardial function at low heart rates in isolated myocardium from failing hearts. | lld:pubmed |
| pubmed-article:16540370 | pubmed:affiliation | Georg-August-Universität Göttingen, Herzzentrum, Kardiologie und Pneumologie, Robert-Koch-Str. 40, 37099 Göttingen, Germany. schiwolf@med.uni-goettingen.de | lld:pubmed |
| pubmed-article:16540370 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16540370 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
