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pubmed-article:16528528pubmed:abstractTextFerredoxin reductase (FDXR) is a putative contributor to p53-mediated apoptosis from 5-fluorouracil (5-FU) through the generation of oxidative stress in the mitochondria. However, the influence of FDXR gene expression levels on the outcome of 5-FU chemotherapy has been relatively little studied. The aim of this study is to investigate the association between FDXR gene expressions and the clinical outcome when treated by 5-FU chemotherapy, as well as the correlation of FDXR gene expressions and p53 mutation.lld:pubmed
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pubmed-article:16528528pubmed:year2006lld:pubmed
pubmed-article:16528528pubmed:articleTitleGene expression of ferredoxin reductase predicts outcome in patients with metastatic colorectal cancer treated by 5-fluorouracil plus leucovorin.lld:pubmed
pubmed-article:16528528pubmed:affiliationDepartment of General and Digestive Surgery, Saitama Medical School, 38, Moro-Hongo, Moroyama, Iruma, 350-049, Saitama, Japan. wataru@saitama-med.ac.jplld:pubmed
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