| pubmed-article:1651669 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1651669 | lifeskim:mentions | umls-concept:C0006675 | lld:lifeskim |
| pubmed-article:1651669 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:1651669 | lifeskim:mentions | umls-concept:C0014609 | lld:lifeskim |
| pubmed-article:1651669 | lifeskim:mentions | umls-concept:C0458827 | lld:lifeskim |
| pubmed-article:1651669 | lifeskim:mentions | umls-concept:C0178719 | lld:lifeskim |
| pubmed-article:1651669 | lifeskim:mentions | umls-concept:C0006100 | lld:lifeskim |
| pubmed-article:1651669 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:1651669 | lifeskim:mentions | umls-concept:C1182794 | lld:lifeskim |
| pubmed-article:1651669 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:1651669 | pubmed:issue | 2 Pt 1 | lld:pubmed |
| pubmed-article:1651669 | pubmed:dateCreated | 1991-9-19 | lld:pubmed |
| pubmed-article:1651669 | pubmed:abstractText | The Ca(2+)-mobilizing action of bradykinin (BK) was investigated in ciliated human nasal epithelial (HNE) cells utilizing fura-2 fluorescence and microspectrofluorimetry. In ciliated cells, basal intracellular Ca2+ concentration ([Ca2+]i) was 123 +/- 3 nM (n = 142). BK caused [Ca2+]i to increase (spike) rapidly (within 6 s) to greater than 550 nM by releasing Ca2+ from intracellular pools. The mean effective dose for the process was 1.5 x 10(-7) M BK. The spike was due to the activation of a beta 2-receptor. The spike was unaffected by inhibitors of either cyclooxygenase or voltagegated Ca2+ channels. After the spike, [Ca2+]i decreased to a plateau level (120-250 nM). This plateau persisted (up to 10 min) until the addition of La3+ (0.3 x 10(-3) M) or until the removal of either extracellular Ca2+ or the agonist. No changes in adenosine 3',5'-cyclic monophosphate (cAMP) levels were detected after BK exposure. Additional studies revealed that indomethacin (10(-6) M), isoproterenol (10(-5) M), forskolin (10(-5) M), and dibutyryl cAMP (1 mM) had no effect on [Ca2+]i in ciliated HNE cells. In summary, these data suggest that 1) BK mediates both Ca2+ release from internal pools and Ca2+ entry into the cytoplasm from the extracellular space, and 2) unlike the response to cultured dog airway epithelia, the release of [Ca2+]i in response to BK does not appear to be mediated by either cyclooxygenase pathway or adenylate cyclase-cAMP systems. | lld:pubmed |
| pubmed-article:1651669 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1651669 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1651669 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1651669 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1651669 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1651669 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1651669 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1651669 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1651669 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1651669 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1651669 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1651669 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1651669 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1651669 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1651669 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:1651669 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:1651669 | pubmed:author | pubmed-author:BoucherR CRC | lld:pubmed |
| pubmed-article:1651669 | pubmed:author | pubmed-author:ChengE HEH | lld:pubmed |
| pubmed-article:1651669 | pubmed:author | pubmed-author:ParadisoA MAM | lld:pubmed |
| pubmed-article:1651669 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1651669 | pubmed:volume | 261 | lld:pubmed |
| pubmed-article:1651669 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1651669 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1651669 | pubmed:pagination | L63-9 | lld:pubmed |
| pubmed-article:1651669 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:1651669 | pubmed:meshHeading | pubmed-meshheading:1651669-... | lld:pubmed |
| pubmed-article:1651669 | pubmed:meshHeading | pubmed-meshheading:1651669-... | lld:pubmed |
| pubmed-article:1651669 | pubmed:meshHeading | pubmed-meshheading:1651669-... | lld:pubmed |
| pubmed-article:1651669 | pubmed:meshHeading | pubmed-meshheading:1651669-... | lld:pubmed |
| pubmed-article:1651669 | pubmed:meshHeading | pubmed-meshheading:1651669-... | lld:pubmed |
| pubmed-article:1651669 | pubmed:meshHeading | pubmed-meshheading:1651669-... | lld:pubmed |
| pubmed-article:1651669 | pubmed:meshHeading | pubmed-meshheading:1651669-... | lld:pubmed |
| pubmed-article:1651669 | pubmed:meshHeading | pubmed-meshheading:1651669-... | lld:pubmed |
| pubmed-article:1651669 | pubmed:meshHeading | pubmed-meshheading:1651669-... | lld:pubmed |
| pubmed-article:1651669 | pubmed:meshHeading | pubmed-meshheading:1651669-... | lld:pubmed |
| pubmed-article:1651669 | pubmed:meshHeading | pubmed-meshheading:1651669-... | lld:pubmed |
| pubmed-article:1651669 | pubmed:meshHeading | pubmed-meshheading:1651669-... | lld:pubmed |
| pubmed-article:1651669 | pubmed:meshHeading | pubmed-meshheading:1651669-... | lld:pubmed |
| pubmed-article:1651669 | pubmed:meshHeading | pubmed-meshheading:1651669-... | lld:pubmed |
| pubmed-article:1651669 | pubmed:meshHeading | pubmed-meshheading:1651669-... | lld:pubmed |
| pubmed-article:1651669 | pubmed:meshHeading | pubmed-meshheading:1651669-... | lld:pubmed |
| pubmed-article:1651669 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1651669 | pubmed:articleTitle | Effects of bradykinin on intracellular calcium regulation in human ciliated airway epithelium. | lld:pubmed |
| pubmed-article:1651669 | pubmed:affiliation | Department of Medicine, University of North Carolina, Chapel Hill 27599. | lld:pubmed |
| pubmed-article:1651669 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1651669 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1651669 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1651669 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1651669 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1651669 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1651669 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1651669 | lld:pubmed |
