| pubmed-article:16507773 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16507773 | lifeskim:mentions | umls-concept:C0026900 | lld:lifeskim |
| pubmed-article:16507773 | lifeskim:mentions | umls-concept:C1510411 | lld:lifeskim |
| pubmed-article:16507773 | lifeskim:mentions | umls-concept:C2323499 | lld:lifeskim |
| pubmed-article:16507773 | lifeskim:mentions | umls-concept:C0072473 | lld:lifeskim |
| pubmed-article:16507773 | lifeskim:mentions | umls-concept:C0205224 | lld:lifeskim |
| pubmed-article:16507773 | lifeskim:mentions | umls-concept:C1521840 | lld:lifeskim |
| pubmed-article:16507773 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:16507773 | pubmed:dateCreated | 2006-6-22 | lld:pubmed |
| pubmed-article:16507773 | pubmed:abstractText | Abdominal-type HoxA genes in combination with Meis1 are well-documented on-cogenes in various leukemias but it is unclear how they exert their transforming function. Here we used a system of conditional transformation by an inducible mixed lineage leukemia-eleven-nineteen leukemia (MLL-ENL) oncoprotein to overexpress Hoxa9 and Meis1 in primary hematopoietic cells. Arrays identified c-Myb and a c-Myb target (Gstm1) among the genes with the strongest response to Hoxa9/Meis1. c-Myb overexpression was verified by Northern blot and quantitative reverse transcription-polymerase chain reaction (RT-PCR). Also MLL-ENL activated c-Myb through up-regulation of Hoxa9 and Meis1. Consequently, short-term suppression of c-Myb by small inhibitory RNA (siRNA) efficiently inhibited transformation by MLL-ENL but did not impair transformation by transcription factor E2A-hepatic leukemia factor (E2A-HLF). The anti c-Myb siRNA effect was abrogated by coexpression of a c-Myb derivative with a mutated siRNA target site. The introduction of a dominant-negative c-Myb mutant had a similar but weaker effect on MLL-ENL-mediated transformation. Hematopoietic precursors from mice homozygous for a hypo-morphic c-Myb allele were more severely affected and could be transformed neither by MLL-ENL nor by E2A-HLF. Ectopic expression of c-Myb induced a differentiation block but c-Myb alone was not transforming in a replating assay similar to Hoxa9/Meis1. These results suggest that c-Myb is essential but not sufficient for Hoxa9/Meis1 mediated transformation. | lld:pubmed |
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| pubmed-article:16507773 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16507773 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16507773 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:16507773 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16507773 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:16507773 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:16507773 | pubmed:author | pubmed-author:SlanyRobert... | lld:pubmed |
| pubmed-article:16507773 | pubmed:author | pubmed-author:FramptonJonJ | lld:pubmed |
| pubmed-article:16507773 | pubmed:author | pubmed-author:HessJay LJL | lld:pubmed |
| pubmed-article:16507773 | pubmed:author | pubmed-author:BorkhardtArnd... | lld:pubmed |
| pubmed-article:16507773 | pubmed:author | pubmed-author:BachChristian... | lld:pubmed |
| pubmed-article:16507773 | pubmed:author | pubmed-author:FuchsUtaU | lld:pubmed |
| pubmed-article:16507773 | pubmed:author | pubmed-author:BittnerClaudi... | lld:pubmed |
| pubmed-article:16507773 | pubmed:author | pubmed-author:ZeisigDeniz... | lld:pubmed |
| pubmed-article:16507773 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16507773 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:16507773 | pubmed:volume | 108 | lld:pubmed |
| pubmed-article:16507773 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16507773 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16507773 | pubmed:pagination | 297-304 | lld:pubmed |
| pubmed-article:16507773 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:16507773 | pubmed:meshHeading | pubmed-meshheading:16507773... | lld:pubmed |
| pubmed-article:16507773 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16507773 | pubmed:articleTitle | c-Myb is an essential downstream target for homeobox-mediated transformation of hematopoietic cells. | lld:pubmed |
