| pubmed-article:16502134 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16502134 | lifeskim:mentions | umls-concept:C0678952 | lld:lifeskim |
| pubmed-article:16502134 | lifeskim:mentions | umls-concept:C0004927 | lld:lifeskim |
| pubmed-article:16502134 | lifeskim:mentions | umls-concept:C0205359 | lld:lifeskim |
| pubmed-article:16502134 | lifeskim:mentions | umls-concept:C0599883 | lld:lifeskim |
| pubmed-article:16502134 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:16502134 | pubmed:dateCreated | 2006-12-7 | lld:pubmed |
| pubmed-article:16502134 | pubmed:abstractText | Outbred Sprague-Dawley rats can be classified as high responders (HR) or low responders (LR) based on their levels of exploratory locomotion in a novel environment. While this novelty-seeking dimension was originally related to differential vulnerability to substance abuse, behavioral, neuroendocrine and gene expression studies suggest a fundamental difference in emotional reactivity between these animals. Here, we report the first study to selectively breed rats based on this novelty-seeking dimension. Response to novelty was clearly heritable, with a > 2-fold difference in behavior seen after eight generations of selection. Three tests of anxiety-like behavior consistently showed significantly greater anxiety in LR-bred rats compared to HR-bred animals, and this difference was diminished in the open field test by administration of the anxiolytic benzodiazepine drug, chlordiazepoxide. Cross-fostering revealed that responses to novelty were largely unaffected by maternal interactions, though there was an effect on anxiety-like behavior. These selected lines will enable future research on the interplay of genetic, environmental and developmental variables in controlling drug seeking behavior, stress and emotional reactivity. | lld:pubmed |
| pubmed-article:16502134 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16502134 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16502134 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16502134 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16502134 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16502134 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16502134 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:16502134 | pubmed:issn | 0001-8244 | lld:pubmed |
| pubmed-article:16502134 | pubmed:author | pubmed-author:NealCharlesC | lld:pubmed |
| pubmed-article:16502134 | pubmed:author | pubmed-author:AkilHudaH | lld:pubmed |
| pubmed-article:16502134 | pubmed:author | pubmed-author:WatsonStanley... | lld:pubmed |
| pubmed-article:16502134 | pubmed:author | pubmed-author:MillerSueS | lld:pubmed |
| pubmed-article:16502134 | pubmed:author | pubmed-author:SteadJohn D... | lld:pubmed |
| pubmed-article:16502134 | pubmed:author | pubmed-author:VazquezDelia... | lld:pubmed |
| pubmed-article:16502134 | pubmed:author | pubmed-author:ClintonSarahS | lld:pubmed |
| pubmed-article:16502134 | pubmed:author | pubmed-author:SchneiderJoha... | lld:pubmed |
| pubmed-article:16502134 | pubmed:author | pubmed-author:JamaAbasA | lld:pubmed |
| pubmed-article:16502134 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16502134 | pubmed:volume | 36 | lld:pubmed |
| pubmed-article:16502134 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16502134 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16502134 | pubmed:pagination | 697-712 | lld:pubmed |
| pubmed-article:16502134 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:16502134 | pubmed:meshHeading | pubmed-meshheading:16502134... | lld:pubmed |
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| pubmed-article:16502134 | pubmed:meshHeading | pubmed-meshheading:16502134... | lld:pubmed |
| pubmed-article:16502134 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16502134 | pubmed:articleTitle | Selective breeding for divergence in novelty-seeking traits: heritability and enrichment in spontaneous anxiety-related behaviors. | lld:pubmed |
| pubmed-article:16502134 | pubmed:affiliation | Institute for Neuroscience, Carleton University, Ottawa, ON, KIS 5B6, Canada. John_Stead@carleton.ca | lld:pubmed |
| pubmed-article:16502134 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16502134 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:16502134 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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