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pubmed-article:16491137pubmed:abstractTextLympho-stromal interactions in multiple microenvironments within the thymus have a crucial role in the regulation of T-cell development and selection. Recent studies have implicated that chemokines that are produced by thymic stromal cells have a pivotal role in positioning developing T cells within the thymus. In this Review, I discuss the importance of stroma-derived chemokines in guiding the traffic of developing thymocytes, with an emphasis on the processes of cortex-to-medulla migration and T-cell-repertoire selection, including central tolerance.lld:pubmed
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pubmed-article:16491137pubmed:articleTitleJourney through the thymus: stromal guides for T-cell development and selection.lld:pubmed
pubmed-article:16491137pubmed:affiliationDivision of Experimental Immunology, Institute for Genome Research, University of Tokushima, 3-18-15 Kuramoto, Tokushima 770-8503, Japan. takahama@genome.tokushima-u.ac.jplld:pubmed
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