| pubmed-article:16477036 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16477036 | lifeskim:mentions | umls-concept:C0679729 | lld:lifeskim |
| pubmed-article:16477036 | lifeskim:mentions | umls-concept:C0596508 | lld:lifeskim |
| pubmed-article:16477036 | lifeskim:mentions | umls-concept:C1512035 | lld:lifeskim |
| pubmed-article:16477036 | lifeskim:mentions | umls-concept:C0025462 | lld:lifeskim |
| pubmed-article:16477036 | lifeskim:mentions | umls-concept:C1516349 | lld:lifeskim |
| pubmed-article:16477036 | lifeskim:mentions | umls-concept:C0031437 | lld:lifeskim |
| pubmed-article:16477036 | lifeskim:mentions | umls-concept:C1418597 | lld:lifeskim |
| pubmed-article:16477036 | lifeskim:mentions | umls-concept:C0162493 | lld:lifeskim |
| pubmed-article:16477036 | lifeskim:mentions | umls-concept:C1417836 | lld:lifeskim |
| pubmed-article:16477036 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:16477036 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:16477036 | pubmed:dateCreated | 2006-5-2 | lld:pubmed |
| pubmed-article:16477036 | pubmed:abstractText | Midbrain dopamine (DA) neurons play a central role in the regulation of voluntary movement, and their degeneration is associated with Parkinson's disease. Cell replacement therapies, and in particular embryonic stem (ES) cell-derived DA neurons, offer a potential therapeutic venue for Parkinson's disease. We sought to identify genes that can potentiate maturation of ES cell cultures to the midbrain DA neuron phenotype. A number of transcription factors have been implicated in the development of midbrain DA neurons by expression analyses and loss-of-function knockout mouse studies, including Nurr1, Pitx3, Lmx1b, Engrailed-1, and Engrailed-2. However, none of these factors appear sufficient alone to induce the mature midbrain DA neuron phenotype in ES cell cultures in vitro, suggesting a more complex regulatory network. Here we show that Nurr1 and Pitx3 cooperatively promote terminal maturation to the midbrain DA neuron phenotype in murine and human ES cell cultures. | lld:pubmed |
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| pubmed-article:16477036 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16477036 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16477036 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16477036 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16477036 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:16477036 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:16477036 | pubmed:author | pubmed-author:JonesE TET | lld:pubmed |
| pubmed-article:16477036 | pubmed:author | pubmed-author:GetherUlrikU | lld:pubmed |
| pubmed-article:16477036 | pubmed:author | pubmed-author:NewmanAmy HAH | lld:pubmed |
| pubmed-article:16477036 | pubmed:author | pubmed-author:BacciJean-Jac... | lld:pubmed |
| pubmed-article:16477036 | pubmed:author | pubmed-author:AbeliovichAsa... | lld:pubmed |
| pubmed-article:16477036 | pubmed:author | pubmed-author:VantiWilliam... | lld:pubmed |
| pubmed-article:16477036 | pubmed:author | pubmed-author:WangHonggangH | lld:pubmed |
| pubmed-article:16477036 | pubmed:author | pubmed-author:MartinatCecil... | lld:pubmed |
| pubmed-article:16477036 | pubmed:author | pubmed-author:LeeteThomasT | lld:pubmed |
| pubmed-article:16477036 | pubmed:author | pubmed-author:KimJongpilJ | lld:pubmed |
| pubmed-article:16477036 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16477036 | pubmed:day | 21 | lld:pubmed |
| pubmed-article:16477036 | pubmed:volume | 103 | lld:pubmed |
| pubmed-article:16477036 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16477036 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16477036 | pubmed:pagination | 2874-9 | lld:pubmed |
| pubmed-article:16477036 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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