| pubmed-article:16467198 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16467198 | lifeskim:mentions | umls-concept:C0600524 | lld:lifeskim |
| pubmed-article:16467198 | lifeskim:mentions | umls-concept:C0024501 | lld:lifeskim |
| pubmed-article:16467198 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:16467198 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:16467198 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:16467198 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:16467198 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:16467198 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:16467198 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:16467198 | lifeskim:mentions | umls-concept:C0205250 | lld:lifeskim |
| pubmed-article:16467198 | lifeskim:mentions | umls-concept:C0721534 | lld:lifeskim |
| pubmed-article:16467198 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:16467198 | pubmed:dateCreated | 2006-6-6 | lld:pubmed |
| pubmed-article:16467198 | pubmed:abstractText | Establishing a CD8(+) T cell-mediated immune correlate of protection in HIV disease is crucial to the development of vaccines designed to generate cell-mediated immunity. Historically, neither the quantity nor breadth of the HIV-specific CD8(+) T-cell response has correlated conclusively with protection. Here, we assess the quality of the HIV-specific CD8(+) T-cell response by measuring 5 CD8(+) T-cell functions (degranulation, IFN-gamma, MIP-1beta, TNF-alpha, and IL-2) simultaneously in chronically HIV-infected individuals and elite nonprogressors. We find that the functional profile of HIV-specific CD8(+) T cells in progressors is limited compared to that of nonprogressors, who consistently maintain highly functional CD8(+) T cells. This limited functionality is independent of HLA type and T-cell memory phenotype, is HIV-specific rather than generalized, and is not effectively restored by therapeutic intervention. Whereas the total HIV-specific CD8(+) T-cell frequency did not correlate with viral load, the frequency and proportion of the HIV-specific T-cell response with highest functionality inversely correlated with viral load in the progressors. Thus, rather than quantity or phenotype, the quality of the CD8(+) T-cell functional response serves as an immune correlate of HIV disease progression and a potential qualifying factor for evaluation of HIV vaccine efficacy. | lld:pubmed |
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| pubmed-article:16467198 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:16467198 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:16467198 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16467198 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:16467198 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:16467198 | pubmed:author | pubmed-author:MiguelesSteph... | lld:pubmed |
| pubmed-article:16467198 | pubmed:author | pubmed-author:ConnorsMarkM | lld:pubmed |
| pubmed-article:16467198 | pubmed:author | pubmed-author:LedermanMicha... | lld:pubmed |
| pubmed-article:16467198 | pubmed:author | pubmed-author:GoepfertPaul... | lld:pubmed |
| pubmed-article:16467198 | pubmed:author | pubmed-author:KoupRichard... | lld:pubmed |
| pubmed-article:16467198 | pubmed:author | pubmed-author:BettsMichael... | lld:pubmed |
| pubmed-article:16467198 | pubmed:author | pubmed-author:RoedererMario... | lld:pubmed |
| pubmed-article:16467198 | pubmed:author | pubmed-author:De... | lld:pubmed |
| pubmed-article:16467198 | pubmed:author | pubmed-author:WestSadie MSM | lld:pubmed |
| pubmed-article:16467198 | pubmed:author | pubmed-author:NasonMartha... | lld:pubmed |
| pubmed-article:16467198 | pubmed:author | pubmed-author:BenitoJose... | lld:pubmed |
| pubmed-article:16467198 | pubmed:author | pubmed-author:AbrahamJonath... | lld:pubmed |
| pubmed-article:16467198 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16467198 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:16467198 | pubmed:volume | 107 | lld:pubmed |
| pubmed-article:16467198 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16467198 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16467198 | pubmed:pagination | 4781-9 | lld:pubmed |
| pubmed-article:16467198 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:16467198 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16467198 | pubmed:articleTitle | HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells. | lld:pubmed |
| pubmed-article:16467198 | pubmed:affiliation | Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. | lld:pubmed |
| pubmed-article:16467198 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16467198 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:16467198 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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