| pubmed-article:16461044 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16461044 | lifeskim:mentions | umls-concept:C0080202 | lld:lifeskim |
| pubmed-article:16461044 | lifeskim:mentions | umls-concept:C0038257 | lld:lifeskim |
| pubmed-article:16461044 | lifeskim:mentions | umls-concept:C1707455 | lld:lifeskim |
| pubmed-article:16461044 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:16461044 | pubmed:dateCreated | 2006-2-7 | lld:pubmed |
| pubmed-article:16461044 | pubmed:abstractText | We sought to investigate the effects of 2 different coronary drug-eluting stents on the distribution of central or effector memory T cells circulating in the coronary sinus of patients with coronary artery disease who underwent percutaneous coronary revascularization. We randomly assigned 43 patients (mean age 65.4 +/- 4.3 years; 34 men) presenting with stable coronary disease and angiographically proved stenosis of the left anterior descending artery to treatment with sirolimus- or paclitaxel-eluting stents. Heparinized blood samples were obtained from the coronary sinus before and 20 minutes after stent implantation. Analysis of surface phenotype was performed by 4-color flow cytometry, and data are expressed as the percentage of positive cells. The percentages of CD8+ and CD4+ effector memory T cells, as defined by the CD3+CD45RO+CD27- phenotype, were significantly reduced in patients who received a sirolimus-eluting stent compared with the basal values. Conversely, the percentages of CD8+, but not CD4+, central memory T cells (CD3+CD45RO+CD27+) were increased in the same treatment group after the revascularization procedure. No changes in the percentages of memory T-cell populations in the paclitaxel-eluting stent group were observed. These findings show that sirolimus-eluting stents rapidly induced a redistribution of memory T lymphocytes, with a significant decrease of proinflammatory effector memory T cells circulating within the coronary sinus. | lld:pubmed |
| pubmed-article:16461044 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16461044 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16461044 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:16461044 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16461044 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16461044 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16461044 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16461044 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:16461044 | pubmed:issn | 0002-9149 | lld:pubmed |
| pubmed-article:16461044 | pubmed:author | pubmed-author:FedeleFrances... | lld:pubmed |
| pubmed-article:16461044 | pubmed:author | pubmed-author:ParoliMarinoM | lld:pubmed |
| pubmed-article:16461044 | pubmed:author | pubmed-author:De... | lld:pubmed |
| pubmed-article:16461044 | pubmed:author | pubmed-author:SardellaGenna... | lld:pubmed |
| pubmed-article:16461044 | pubmed:author | pubmed-author:Di... | lld:pubmed |
| pubmed-article:16461044 | pubmed:author | pubmed-author:De... | lld:pubmed |
| pubmed-article:16461044 | pubmed:author | pubmed-author:ContiGiuliaG | lld:pubmed |
| pubmed-article:16461044 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16461044 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:16461044 | pubmed:volume | 97 | lld:pubmed |
| pubmed-article:16461044 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16461044 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16461044 | pubmed:pagination | 494-8 | lld:pubmed |
| pubmed-article:16461044 | pubmed:meshHeading | pubmed-meshheading:16461044... | lld:pubmed |
| pubmed-article:16461044 | pubmed:meshHeading | pubmed-meshheading:16461044... | lld:pubmed |
| pubmed-article:16461044 | pubmed:meshHeading | pubmed-meshheading:16461044... | lld:pubmed |
| pubmed-article:16461044 | pubmed:meshHeading | pubmed-meshheading:16461044... | lld:pubmed |
| pubmed-article:16461044 | pubmed:meshHeading | pubmed-meshheading:16461044... | lld:pubmed |
| pubmed-article:16461044 | pubmed:meshHeading | pubmed-meshheading:16461044... | lld:pubmed |
| pubmed-article:16461044 | pubmed:meshHeading | pubmed-meshheading:16461044... | lld:pubmed |
| pubmed-article:16461044 | pubmed:meshHeading | pubmed-meshheading:16461044... | lld:pubmed |
| pubmed-article:16461044 | pubmed:meshHeading | pubmed-meshheading:16461044... | lld:pubmed |
| pubmed-article:16461044 | pubmed:meshHeading | pubmed-meshheading:16461044... | lld:pubmed |
| pubmed-article:16461044 | pubmed:meshHeading | pubmed-meshheading:16461044... | lld:pubmed |
| pubmed-article:16461044 | pubmed:meshHeading | pubmed-meshheading:16461044... | lld:pubmed |
| pubmed-article:16461044 | pubmed:meshHeading | pubmed-meshheading:16461044... | lld:pubmed |
| pubmed-article:16461044 | pubmed:meshHeading | pubmed-meshheading:16461044... | lld:pubmed |
| pubmed-article:16461044 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16461044 | pubmed:articleTitle | Comparison between sirolimus- and paclitaxel-eluting stent in T-cell subsets redistribution. | lld:pubmed |
| pubmed-article:16461044 | pubmed:affiliation | Dipartimento di Scienze Cardiovascolari e Respiratorie, Università La Sapienza, Rome, Italy. rino.sardella@uniroma1.it | lld:pubmed |
| pubmed-article:16461044 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16461044 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
