| pubmed-article:16445925 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16445925 | lifeskim:mentions | umls-concept:C0872318 | lld:lifeskim |
| pubmed-article:16445925 | lifeskim:mentions | umls-concept:C0185125 | lld:lifeskim |
| pubmed-article:16445925 | lifeskim:mentions | umls-concept:C2347946 | lld:lifeskim |
| pubmed-article:16445925 | lifeskim:mentions | umls-concept:C0205198 | lld:lifeskim |
| pubmed-article:16445925 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:16445925 | pubmed:dateCreated | 2006-6-19 | lld:pubmed |
| pubmed-article:16445925 | pubmed:abstractText | Mixtures of hexane-like ethoxynonafluorobutane with alcohols were used as MS-friendly mobile phases for separation and efficient detection of non-UV-active enantiomers and diastereomers using normal-phase HPLC-APCI-MS. Racemic muscone, camphorsulfonamide, camphorsultam, BOC-protected 1-(3-aminopropyl)-2-pipecoline and diastereomeric 2-methylhexanoyl camphorsultams were resolved on Chiralpak AS and AD and achiral Luna CN columns. The responses of UV and APCI-MS detectors were compared under separation conditions studied, with MS detection achieving lowest detectable quantity in the range of 0.5-2 ng per chromatographic peak. The absolute configuration of crystalline derivatives of racemic 2-methylhexanoic acid with (S)-(-)-2,10-camphorsultam was determined by X-ray analysis after their automatic purification by preparative LC-MS. The technique described can be used to purify and determine the absolute stereochemistry of compounds of unknown structure which contain free carboxy group and lack sufficient UV absorbance. | lld:pubmed |
| pubmed-article:16445925 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16445925 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16445925 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16445925 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16445925 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16445925 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16445925 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16445925 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16445925 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16445925 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16445925 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:16445925 | pubmed:issn | 0021-9673 | lld:pubmed |
| pubmed-article:16445925 | pubmed:author | pubmed-author:HuD WDW | lld:pubmed |
| pubmed-article:16445925 | pubmed:author | pubmed-author:GreenfieldAA | lld:pubmed |
| pubmed-article:16445925 | pubmed:author | pubmed-author:KaganMM | lld:pubmed |
| pubmed-article:16445925 | pubmed:author | pubmed-author:ChlenovMM | lld:pubmed |
| pubmed-article:16445925 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16445925 | pubmed:day | 7 | lld:pubmed |
| pubmed-article:16445925 | pubmed:volume | 1120 | lld:pubmed |
| pubmed-article:16445925 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16445925 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16445925 | pubmed:pagination | 82-8 | lld:pubmed |
| pubmed-article:16445925 | pubmed:dateRevised | 2009-1-15 | lld:pubmed |
| pubmed-article:16445925 | pubmed:meshHeading | pubmed-meshheading:16445925... | lld:pubmed |
| pubmed-article:16445925 | pubmed:meshHeading | pubmed-meshheading:16445925... | lld:pubmed |
| pubmed-article:16445925 | pubmed:meshHeading | pubmed-meshheading:16445925... | lld:pubmed |
| pubmed-article:16445925 | pubmed:meshHeading | pubmed-meshheading:16445925... | lld:pubmed |
| pubmed-article:16445925 | pubmed:meshHeading | pubmed-meshheading:16445925... | lld:pubmed |
| pubmed-article:16445925 | pubmed:meshHeading | pubmed-meshheading:16445925... | lld:pubmed |
| pubmed-article:16445925 | pubmed:meshHeading | pubmed-meshheading:16445925... | lld:pubmed |
| pubmed-article:16445925 | pubmed:meshHeading | pubmed-meshheading:16445925... | lld:pubmed |
| pubmed-article:16445925 | pubmed:meshHeading | pubmed-meshheading:16445925... | lld:pubmed |
| pubmed-article:16445925 | pubmed:meshHeading | pubmed-meshheading:16445925... | lld:pubmed |
| pubmed-article:16445925 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16445925 | pubmed:articleTitle | Normal-phase chiral liquid chromatography-mass spectrometry of non-UV-active compounds: applications for pharmaceutically relevant racemates. | lld:pubmed |
| pubmed-article:16445925 | pubmed:affiliation | Discovery Analytical Chemistry, Chemical Sciences, Wyeth Research, CN 8000, Princeton, NJ 08540, USA. kaganm@wyeth.com | lld:pubmed |
| pubmed-article:16445925 | pubmed:publicationType | Journal Article | lld:pubmed |
