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pubmed-article:16397035pubmed:abstractTextIn clinical cancer trials for evaluating neoadjuvant chemotherapy, tumor downstaging is frequently used as a surrogate end point for overall survival. We evaluated the surrogacy of tumor downstaging using data from a follow-up observational study in bladder cancer.lld:pubmed
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pubmed-article:16397035pubmed:articleTitleEvaluation for surrogacy of end points by using data from observational studies: tumor downstaging for evaluating neoadjuvant chemotherapy in invasive bladder cancer.lld:pubmed
pubmed-article:16397035pubmed:affiliationDepartment of Clinical Trial Design and Management, Translational Research Center, Kyoto University Hospital, Kyoto, Japan. steramu@kuhp.kyoto-u.ac.jplld:pubmed
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