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pubmed-article:16377712pubmed:abstractTextInhibition of DNA replication in an Escherichia coli dnaB-22 mutant failed to block quinolone-mediated lethality. Inhibition of protein synthesis by chloramphenicol inhibited nalidixic acid lethality and, to a lesser extent, ciprofloxacin lethality in both dnaB-22 and wild-type cells. Thus, major features of quinolone-mediated lethality do not depend on ongoing replication.lld:pubmed
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pubmed-article:16377712pubmed:articleTitleLethal action of quinolones against a temperature-sensitive dnaB replication mutant of Escherichia coli.lld:pubmed
pubmed-article:16377712pubmed:affiliationPublic Health Research Institute, 225 Warren St., Newark, New Jersey 07103, USA.lld:pubmed
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