| pubmed-article:16371226 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16371226 | lifeskim:mentions | umls-concept:C0028128 | lld:lifeskim |
| pubmed-article:16371226 | lifeskim:mentions | umls-concept:C0026845 | lld:lifeskim |
| pubmed-article:16371226 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:16371226 | lifeskim:mentions | umls-concept:C1097411 | lld:lifeskim |
| pubmed-article:16371226 | lifeskim:mentions | umls-concept:C0035028 | lld:lifeskim |
| pubmed-article:16371226 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:16371226 | lifeskim:mentions | umls-concept:C0965412 | lld:lifeskim |
| pubmed-article:16371226 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:16371226 | pubmed:dateCreated | 2006-1-9 | lld:pubmed |
| pubmed-article:16371226 | pubmed:abstractText | The compound BAY 41-2272 stimulates the soluble guanylyl cyclase in a nitric oxide (NO)-independent manner. We have investigated the potency and efficacy of BAY 41-2272 in the rat anococcygeus muscle, as well as the effects of BAY 41-2272 on NO-mediated anococcygeus relaxations. BAY 41-2272 (0.01-10 microM) potently relaxed precontracted anococcygeus muscle strips, with a pEC(50) value of 6.44 +/- 0.03 and maximum response of 100 +/- 2%. The soluble guanylyl cyclase inhibitor 1H-[1,2,4]-oxidiazolo[4,3-a] quinoxalin-1-one (ODQ, 1 microM) and the NO inhibitor N(omega)-nitro-L-arginine methyl ester (L-NAME, 100 microM) caused significant rightward shifts in the concentration-response curves to BAY 41-2272. The phosphodiesterase type-5 inhibitor tadalafil (0.1 microM) markedly enhanced the relaxations evoked by BAY 41-2272. In addition, BAY 41-2272 increased the duration of nitrergic relaxations by approximately 55%. The relaxations induced by glyceryl trinitrate were also significantly potentiated by BAY 41-2272. In conclusion, BAY 41-2272 interacts with endogenous and exogenous NO causing a potent relaxation of rat anococcygeus muscle. | lld:pubmed |
| pubmed-article:16371226 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:16371226 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16371226 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371226 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371226 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371226 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371226 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371226 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371226 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371226 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371226 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16371226 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371226 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371226 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16371226 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371226 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16371226 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:16371226 | pubmed:issn | 0014-2999 | lld:pubmed |
| pubmed-article:16371226 | pubmed:author | pubmed-author:De... | lld:pubmed |
| pubmed-article:16371226 | pubmed:author | pubmed-author:AntunesEdsonE | lld:pubmed |
| pubmed-article:16371226 | pubmed:author | pubmed-author:WebbR... | lld:pubmed |
| pubmed-article:16371226 | pubmed:author | pubmed-author:PrivieroFerna... | lld:pubmed |
| pubmed-article:16371226 | pubmed:author | pubmed-author:TeixeiraClebe... | lld:pubmed |
| pubmed-article:16371226 | pubmed:author | pubmed-author:BaracatJulian... | lld:pubmed |
| pubmed-article:16371226 | pubmed:author | pubmed-author:ClaudinoMário... | lld:pubmed |
| pubmed-article:16371226 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16371226 | pubmed:day | 13 | lld:pubmed |
| pubmed-article:16371226 | pubmed:volume | 530 | lld:pubmed |
| pubmed-article:16371226 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16371226 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16371226 | pubmed:pagination | 157-65 | lld:pubmed |
| pubmed-article:16371226 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:16371226 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16371226 | pubmed:articleTitle | Stimulation of soluble guanylyl cyclase by BAY 41-2272 relaxes anococcygeus muscle: interaction with nitric oxide. | lld:pubmed |
| pubmed-article:16371226 | pubmed:affiliation | Department of Pharmacology, Faculty of Medical Sciences, UNICAMP, Campinas (SP), Brazil. | lld:pubmed |
| pubmed-article:16371226 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16371226 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:16371226 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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