| pubmed-article:16358615 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16358615 | lifeskim:mentions | umls-concept:C0006142 | lld:lifeskim |
| pubmed-article:16358615 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:16358615 | lifeskim:mentions | umls-concept:C0543467 | lld:lifeskim |
| pubmed-article:16358615 | lifeskim:mentions | umls-concept:C0439660 | lld:lifeskim |
| pubmed-article:16358615 | lifeskim:mentions | umls-concept:C1456501 | lld:lifeskim |
| pubmed-article:16358615 | pubmed:issue | 48 | lld:pubmed |
| pubmed-article:16358615 | pubmed:dateCreated | 2005-12-19 | lld:pubmed |
| pubmed-article:16358615 | pubmed:abstractText | Preventive surgical procedures for inherited risk of breast cancer Forwomen with a demonstrated BRCA1 or BRCA2 mutation, the cumulative risk of developing invasive breast cancer before the age of 70 years is about 50-85% and the risk of developing invasive epithelial ovarian cancer is 20-60%. Regular surveillance including physical examination and imaging is offered to mutation carriers and the options for risk-reducing surgery are discussed. Although bilateral prophylactic mastectomy is a drastic intervention, it significantly reduces the incidence of breast cancer. For mutation carriers with breast cancer, the decision to combine risk-reducing surgery with treatment is determined by the TNM stage of the disease. Prophylactic bi- or contralateral mastectomy after previous treatment for unilateral breast cancer reduces the incidence of contralateral breast cancer, but has no impact on survival. The complexity of the problem demands a multidisciplinary approach within the context of a family cancer clinic. | lld:pubmed |
| pubmed-article:16358615 | pubmed:language | dut | lld:pubmed |
| pubmed-article:16358615 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16358615 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16358615 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16358615 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16358615 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16358615 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:16358615 | pubmed:issn | 0028-2162 | lld:pubmed |
| pubmed-article:16358615 | pubmed:author | pubmed-author:van GeelA NAN | lld:pubmed |
| pubmed-article:16358615 | pubmed:author | pubmed-author:Meijers-Heijb... | lld:pubmed |
| pubmed-article:16358615 | pubmed:author | pubmed-author:SeynaeveCC | lld:pubmed |
| pubmed-article:16358615 | pubmed:author | pubmed-author:EggermontA... | lld:pubmed |
| pubmed-article:16358615 | pubmed:author | pubmed-author:KlijnJ G MJG | lld:pubmed |
| pubmed-article:16358615 | pubmed:author | pubmed-author:Menke-Pluymer... | lld:pubmed |
| pubmed-article:16358615 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16358615 | pubmed:day | 26 | lld:pubmed |
| pubmed-article:16358615 | pubmed:volume | 149 | lld:pubmed |
| pubmed-article:16358615 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16358615 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16358615 | pubmed:pagination | 2663-7 | lld:pubmed |
| pubmed-article:16358615 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:16358615 | pubmed:meshHeading | pubmed-meshheading:16358615... | lld:pubmed |
| pubmed-article:16358615 | pubmed:meshHeading | pubmed-meshheading:16358615... | lld:pubmed |
| pubmed-article:16358615 | pubmed:meshHeading | pubmed-meshheading:16358615... | lld:pubmed |
| pubmed-article:16358615 | pubmed:meshHeading | pubmed-meshheading:16358615... | lld:pubmed |
| pubmed-article:16358615 | pubmed:meshHeading | pubmed-meshheading:16358615... | lld:pubmed |
| pubmed-article:16358615 | pubmed:meshHeading | pubmed-meshheading:16358615... | lld:pubmed |
| pubmed-article:16358615 | pubmed:meshHeading | pubmed-meshheading:16358615... | lld:pubmed |
| pubmed-article:16358615 | pubmed:meshHeading | pubmed-meshheading:16358615... | lld:pubmed |
| pubmed-article:16358615 | pubmed:meshHeading | pubmed-meshheading:16358615... | lld:pubmed |
| pubmed-article:16358615 | pubmed:meshHeading | pubmed-meshheading:16358615... | lld:pubmed |
| pubmed-article:16358615 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16358615 | pubmed:articleTitle | [Preventive surgical prcedures for inherited risk of breast cancer]. | lld:pubmed |
| pubmed-article:16358615 | pubmed:affiliation | Erasmus MC-Daniel den Hoed Oncologisch Centrum, Postbus 5201, 3008 AE Rotterdam. m.menke@erasmusmc.nl | lld:pubmed |
| pubmed-article:16358615 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16358615 | pubmed:publicationType | English Abstract | lld:pubmed |
| pubmed-article:16358615 | pubmed:publicationType | Review | lld:pubmed |
