| pubmed-article:16354706 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16354706 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:16354706 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:16354706 | lifeskim:mentions | umls-concept:C1332712 | lld:lifeskim |
| pubmed-article:16354706 | lifeskim:mentions | umls-concept:C1269955 | lld:lifeskim |
| pubmed-article:16354706 | lifeskim:mentions | umls-concept:C0002345 | lld:lifeskim |
| pubmed-article:16354706 | lifeskim:mentions | umls-concept:C1424457 | lld:lifeskim |
| pubmed-article:16354706 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:16354706 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:16354706 | pubmed:dateCreated | 2005-12-15 | lld:pubmed |
| pubmed-article:16354706 | pubmed:abstractText | The multiple isoforms of the transmembrane glycoprotein CD44 are produced by alternative RNA splicing. Expression of CD44 isoforms containing variable 5 exon (v5) correlates with enhanced malignancy and invasiveness of some tumors. Here we demonstrate that SRm160, a splicing coactivator, regulates CD44 alternative splicing in a Ras-dependent manner. Overexpression of SRm160 stimulates inclusion of CD44 v5 when Ras is activated. Conversely, small interfering RNA (siRNA)-mediated silencing of SRm160 significantly reduces v5 inclusion. Immunoprecipitation shows association of SRm160 with Sam68, a protein that also stimulates v5 inclusion in a Ras-dependent manner, suggesting that these two proteins interact to regulate CD44 splicing. Importantly, siRNA-mediated depletion of CD44 v5 decreases tumor cell invasion. Reduction of SRm160 by siRNA transfection downregulates the endogenous levels of CD44 isoforms, including v5, and correlates with a decrease in tumor cell invasiveness. | lld:pubmed |
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| pubmed-article:16354706 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16354706 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16354706 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16354706 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16354706 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16354706 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16354706 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16354706 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16354706 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16354706 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:16354706 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:16354706 | pubmed:author | pubmed-author:SharpPhillip... | lld:pubmed |
| pubmed-article:16354706 | pubmed:author | pubmed-author:ChengChonghui... | lld:pubmed |
| pubmed-article:16354706 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16354706 | pubmed:volume | 26 | lld:pubmed |
| pubmed-article:16354706 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16354706 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16354706 | pubmed:pagination | 362-70 | lld:pubmed |
| pubmed-article:16354706 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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