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pubmed-article:16352964pubmed:abstractTextDisturbances of intestinal microcirculation associated with sepsis and septic shock result in diminished mucosal oxygenation. Tissue hypoxia as well as mediator formation may lead to intestinal mucosa dysfunction. As a consequence, bacteria and their products as well as gut-derived inflammatory mediators may further perpetuate septic and inflammatory events. Adrenomedullin is produced in the mucosa of the gastrointestinal tract and has been shown to improve survival in experimental sepsis. Using pore-forming Staphylococcus aureus alpha-toxin as a potent initiator of inflammatory reactions, we tested the hypothesis that exogenously added adrenomedullin improves ileal mucosal perfusion.lld:pubmed
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pubmed-article:16352964pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:16352964pubmed:articleTitleAdrenomedullin treatment abolishes ileal mucosal hypoperfusion induced by Staphylococcus aureus alpha-toxin--an intravital microscopic study on an isolated rat ileum.lld:pubmed
pubmed-article:16352964pubmed:affiliationDepartment of Internal Medicine/Infectious Diseases, Charité-University Medicine Berlin, Berlin, Germany.lld:pubmed
pubmed-article:16352964pubmed:publicationTypeJournal Articlelld:pubmed
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