| pubmed-article:16336627 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16336627 | lifeskim:mentions | umls-concept:C0021289 | lld:lifeskim |
| pubmed-article:16336627 | lifeskim:mentions | umls-concept:C0270611 | lld:lifeskim |
| pubmed-article:16336627 | lifeskim:mentions | umls-concept:C0439064 | lld:lifeskim |
| pubmed-article:16336627 | lifeskim:mentions | umls-concept:C0598958 | lld:lifeskim |
| pubmed-article:16336627 | lifeskim:mentions | umls-concept:C0071649 | lld:lifeskim |
| pubmed-article:16336627 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:16336627 | lifeskim:mentions | umls-concept:C0051561 | lld:lifeskim |
| pubmed-article:16336627 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:16336627 | pubmed:dateCreated | 2005-12-22 | lld:pubmed |
| pubmed-article:16336627 | pubmed:abstractText | Flavonoids are naturally occurring polyphenolic compounds that have many biological properties, including antioxidative, anti-inflammatory and neuroprotective effects. Here, we report that amentoflavone significantly reduced cell death induced by staurosporine, etoposide and sodium nitroprusside in neuroblastoma SH-SY5Y cells. In post-natal day 7 rats, hypoxic-ischemic (H-I) brain damage induced by unilateral carotid ligation and hypoxia resulted in distinct features of neuronal cell death including apoptosis and necrosis. In this model, a systemic administration of amentoflavone (30 mg/kg) markedly reduced the H-I-induced brain tissue loss with a wide therapeutic time window up to 6 h after the onset of hypoxia. Amentoflavone blocked the activation of caspase 3, characteristic of apoptosis, and the proteolytic cleavage of its substrates following H-I injury. Amentoflavone also reduced the excitotoxic/necrotic cell death after H-I injury in vivo and after oxygen/glucose deprivation in mouse mixed cultures in vitro. Treatment of mouse microglial cells with amentoflavone resulted in a significant decrease in the lipopolysaccharide-induced production of nitric oxide and induction of inducible nitric oxide synthase and cyclo-oxygenase-2. Furthermore, amentoflavone decreased the inflammatory activation of microglia after H-I injury when assessed by the microglial-specific marker OX-42. These data demonstrate for the first time that amentoflavone strongly protects the neonatal brain from H-I injury by blocking multiple cellular events leading to brain damage. | lld:pubmed |
| pubmed-article:16336627 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16336627 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16336627 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16336627 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16336627 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16336627 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16336627 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16336627 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16336627 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16336627 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16336627 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16336627 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:16336627 | pubmed:issn | 0022-3042 | lld:pubmed |
| pubmed-article:16336627 | pubmed:author | pubmed-author:HanByung... | lld:pubmed |
| pubmed-article:16336627 | pubmed:author | pubmed-author:KimWon-KiWK | lld:pubmed |
| pubmed-article:16336627 | pubmed:author | pubmed-author:ShinDong... | lld:pubmed |
| pubmed-article:16336627 | pubmed:author | pubmed-author:Kim-HanJeong... | lld:pubmed |
| pubmed-article:16336627 | pubmed:author | pubmed-author:SonKun HoKH | lld:pubmed |
| pubmed-article:16336627 | pubmed:author | pubmed-author:KangSam SikSS | lld:pubmed |
| pubmed-article:16336627 | pubmed:author | pubmed-author:ChoiIn... | lld:pubmed |
| pubmed-article:16336627 | pubmed:author | pubmed-author:LeeJi HyunJH | lld:pubmed |
| pubmed-article:16336627 | pubmed:author | pubmed-author:BaeYoung... | lld:pubmed |
| pubmed-article:16336627 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16336627 | pubmed:volume | 96 | lld:pubmed |
| pubmed-article:16336627 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16336627 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16336627 | pubmed:pagination | 561-72 | lld:pubmed |
| pubmed-article:16336627 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:16336627 | pubmed:meshHeading | pubmed-meshheading:16336627... | lld:pubmed |
| pubmed-article:16336627 | pubmed:meshHeading | pubmed-meshheading:16336627... | lld:pubmed |
| pubmed-article:16336627 | pubmed:meshHeading | pubmed-meshheading:16336627... | lld:pubmed |
| pubmed-article:16336627 | pubmed:meshHeading | pubmed-meshheading:16336627... | lld:pubmed |
| pubmed-article:16336627 | pubmed:meshHeading | pubmed-meshheading:16336627... | lld:pubmed |
| pubmed-article:16336627 | pubmed:meshHeading | pubmed-meshheading:16336627... | lld:pubmed |
| pubmed-article:16336627 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16336627 | pubmed:articleTitle | Polyphenol amentoflavone affords neuroprotection against neonatal hypoxic-ischemic brain damage via multiple mechanisms. | lld:pubmed |
| pubmed-article:16336627 | pubmed:affiliation | Department of Manufacturing Pharmacy and Natural Products Research Institute, Seoul National University, Seoul, Republic of Korea. | lld:pubmed |
| pubmed-article:16336627 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16336627 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16336627 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16336627 | lld:pubmed |
