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pubmed-article:16332719pubmed:abstractTextWe report a rare case in which two tumor entities, a gastrointestinal stromal tumor (GIST) and Ewing sarcoma/primitive neuroectodermal tumor (ES/PNET), with distinct cytogenetic features occurred in a single patient. The patient was a 72-year-old woman. The first tumor was a submucosal gastric tumor and was diagnosed as a low-risk group GIST based on morphological characteristics and the results of an immunohistochemical analysis for c-kit and CD34. Further cytogenetic analysis revealed that this tumor had a point mutation (D842V substitution) in exon 18 of the platelet-derived growth factor receptor alpha gene. The second tumor was found more than 4 years after the appearance of the first tumor. ES/PNET was highly suspected both morphologically and immunohistochemically, and the diagnosis was confirmed by the detection of an EWS rearrangement using a fluorescence in situ hybridization technique. Although the cytogenetic correlations of these two tumors are unclear, accurate histologic recognition is of clinical importance because the treatments for these two tumors differ.lld:pubmed
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pubmed-article:16332719pubmed:pagination753-6lld:pubmed
pubmed-article:16332719pubmed:dateRevised2011-11-17lld:pubmed
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pubmed-article:16332719pubmed:year2005lld:pubmed
pubmed-article:16332719pubmed:articleTitleCytogenetic confirmation of a gastrointestinal stromal tumor and ewing sarcoma/primitive neuroectodermal tumor in a single patient.lld:pubmed
pubmed-article:16332719pubmed:affiliationDivison of Medical Oncology, National Cancer Center Hospital, Tokyo, Japan.lld:pubmed
pubmed-article:16332719pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:16332719pubmed:publicationTypeCase Reportslld:pubmed
pubmed-article:16332719pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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