| pubmed-article:16327431 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16327431 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:16327431 | lifeskim:mentions | umls-concept:C0529099 | lld:lifeskim |
| pubmed-article:16327431 | lifeskim:mentions | umls-concept:C1274040 | lld:lifeskim |
| pubmed-article:16327431 | lifeskim:mentions | umls-concept:C0014599 | lld:lifeskim |
| pubmed-article:16327431 | lifeskim:mentions | umls-concept:C0237881 | lld:lifeskim |
| pubmed-article:16327431 | lifeskim:mentions | umls-concept:C0220901 | lld:lifeskim |
| pubmed-article:16327431 | lifeskim:mentions | umls-concept:C0750502 | lld:lifeskim |
| pubmed-article:16327431 | lifeskim:mentions | umls-concept:C0205309 | lld:lifeskim |
| pubmed-article:16327431 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:16327431 | pubmed:dateCreated | 2005-12-5 | lld:pubmed |
| pubmed-article:16327431 | pubmed:abstractText | The prognostic significance of ER-alpha expression in benign proliferative breast disease has been confirmed in epithelial hyperplasia of usual type (HUT). However, little is known about the role of ER-beta in these lesions. Therefore, this study was performed to test the hypothesis that, in HUT lesions, the ratio of ER-alpha:ER-beta is an accurate determinant of breast cancer risk and of predicting subsequent progression to invasive breast cancer. This case-control study analyzed a cohort of benign proliferative breast lesions and foci of ductal HUT in 117 patients with long follow-up (20 years). These foci were analyzed by morphometric image analysis together with immunohistochemistry using monoclonal antibodies to ER-beta1 and to ER-alpha. The data were compared with ER-beta expression in all breast carcinomas that subsequently developed in the same patients as well as to ER-alpha expression in the corresponding tissues. In cases that progressed to carcinoma, the ratio of ER-alpha to ER-beta in HUT was significantly higher (P < 0.001) than in those that did not progress. None of the HUT foci from patients who progressed to breast cancer were simultaneously ER-alpha negative and ER-beta positive. Using both ER-beta and ER-alpha in a logistic model demonstrated a 75% correct classification rate for the cohort studied. These findings confirm the diagnostic and prognostic value of defining the ER-alpha and ER-beta status of HUT lesions identified morphologically. The data support the hypothesis that high ER-alpha:ER-beta levels characterize those cases within HUT likely to progress to breast cancer. The data also reveal that a reduced level of ER-beta relative to ER-alpha is an accurate predictor of individual cases of HUT likely to progress to invasive breast carcinoma, thus supporting the concept that ER-alpha transcriptional activity is directly modulated by ER-beta. | lld:pubmed |
| pubmed-article:16327431 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16327431 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16327431 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16327431 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16327431 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16327431 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16327431 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:16327431 | pubmed:issn | 0147-5185 | lld:pubmed |
| pubmed-article:16327431 | pubmed:author | pubmed-author:ShaabanAbeer... | lld:pubmed |
| pubmed-article:16327431 | pubmed:author | pubmed-author:FosterChristo... | lld:pubmed |
| pubmed-article:16327431 | pubmed:author | pubmed-author:JarvisChristi... | lld:pubmed |
| pubmed-article:16327431 | pubmed:author | pubmed-author:DodsonAndrewA | lld:pubmed |
| pubmed-article:16327431 | pubmed:author | pubmed-author:WestChristoph... | lld:pubmed |
| pubmed-article:16327431 | pubmed:author | pubmed-author:MooreFilF | lld:pubmed |
| pubmed-article:16327431 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16327431 | pubmed:volume | 29 | lld:pubmed |
| pubmed-article:16327431 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16327431 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16327431 | pubmed:pagination | 1593-9 | lld:pubmed |
| pubmed-article:16327431 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:16327431 | pubmed:meshHeading | pubmed-meshheading:16327431... | lld:pubmed |
| pubmed-article:16327431 | pubmed:meshHeading | pubmed-meshheading:16327431... | lld:pubmed |
| pubmed-article:16327431 | pubmed:meshHeading | pubmed-meshheading:16327431... | lld:pubmed |
| pubmed-article:16327431 | pubmed:meshHeading | pubmed-meshheading:16327431... | lld:pubmed |
| pubmed-article:16327431 | pubmed:meshHeading | pubmed-meshheading:16327431... | lld:pubmed |
| pubmed-article:16327431 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16327431 | pubmed:articleTitle | Prognostic significance of estrogen receptor Beta in epithelial hyperplasia of usual type with known outcome. | lld:pubmed |
| pubmed-article:16327431 | pubmed:affiliation | Departments of Cellular and Molecular Pathology, University of Liverpool, Liverpool, UK. | lld:pubmed |
| pubmed-article:16327431 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16327431 | pubmed:publicationType | Comparative Study | lld:pubmed |
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