| pubmed-article:16314515 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16314515 | lifeskim:mentions | umls-concept:C0006104 | lld:lifeskim |
| pubmed-article:16314515 | lifeskim:mentions | umls-concept:C0007776 | lld:lifeskim |
| pubmed-article:16314515 | lifeskim:mentions | umls-concept:C0022655 | lld:lifeskim |
| pubmed-article:16314515 | lifeskim:mentions | umls-concept:C0001613 | lld:lifeskim |
| pubmed-article:16314515 | lifeskim:mentions | umls-concept:C0014556 | lld:lifeskim |
| pubmed-article:16314515 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:16314515 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:16314515 | lifeskim:mentions | umls-concept:C1539970 | lld:lifeskim |
| pubmed-article:16314515 | lifeskim:mentions | umls-concept:C0920533 | lld:lifeskim |
| pubmed-article:16314515 | lifeskim:mentions | umls-concept:C1159970 | lld:lifeskim |
| pubmed-article:16314515 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:16314515 | pubmed:issue | 24 | lld:pubmed |
| pubmed-article:16314515 | pubmed:dateCreated | 2005-11-29 | lld:pubmed |
| pubmed-article:16314515 | pubmed:abstractText | Groucho (Gro)/TLE transcriptional corepressors are involved in a variety of developmental mechanisms, including neuronal differentiation. They contain a conserved C-terminal WD40 repeat domain that mediates interactions with several DNA-binding proteins. In particular, Gro/TLE1 interacts with forkhead transcription factor brain factor 1 (BF-1; also termed FoxG1). BF-1 is an essential regulator of neuronal differentiation during cerebral cortex development and represses transcription together with Gro/TLE1. Gro/TLE-related gene product 6 (Grg6) shares with Gro/TLEs a conserved WD40 repeat domain but is more distantly related at its N-terminal half. We demonstrate that Grg6 is expressed in cortical neural progenitor cells and interacts with BF-1. In contrast to Gro/TLE1, however, Grg6 does not promote, but rather suppresses, BF-1-mediated transcriptional repression. Consistent with these observations, Grg6 interferes with the binding of Gro/TLE1 to BF-1 and does not repress transcription when targeted to DNA. Moreover, coexpression of Grg6 and BF-1 in cortical progenitor cells leads to a decrease in the number of proliferating cells and increased neuronal differentiation. Conversely, Grg6 knockdown by RNA interference causes decreased neurogenesis. These results identify a new role for Grg6 in cortical neuron development and establish a functional link between Grg6 and BF-1. | lld:pubmed |
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| pubmed-article:16314515 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16314515 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16314515 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16314515 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16314515 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:16314515 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:16314515 | pubmed:author | pubmed-author:StifaniStefan... | lld:pubmed |
| pubmed-article:16314515 | pubmed:author | pubmed-author:HelgasonChery... | lld:pubmed |
| pubmed-article:16314515 | pubmed:author | pubmed-author:DangJinjunJ | lld:pubmed |
| pubmed-article:16314515 | pubmed:author | pubmed-author:PatelHarshila... | lld:pubmed |
| pubmed-article:16314515 | pubmed:author | pubmed-author:HoffmanBradB | lld:pubmed |
| pubmed-article:16314515 | pubmed:author | pubmed-author:DongZhifengZ | lld:pubmed |
| pubmed-article:16314515 | pubmed:author | pubmed-author:MarçalNathali... | lld:pubmed |
| pubmed-article:16314515 | pubmed:author | pubmed-author:Belanger-Jasm... | lld:pubmed |
| pubmed-article:16314515 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16314515 | pubmed:volume | 25 | lld:pubmed |
| pubmed-article:16314515 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16314515 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16314515 | pubmed:pagination | 10916-29 | lld:pubmed |
| pubmed-article:16314515 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:16314515 | pubmed:meshHeading | pubmed-meshheading:16314515... | lld:pubmed |
| pubmed-article:16314515 | pubmed:meshHeading | pubmed-meshheading:16314515... | lld:pubmed |
| pubmed-article:16314515 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16314515 | pubmed:articleTitle | Antagonistic effects of Grg6 and Groucho/TLE on the transcription repression activity of brain factor 1/FoxG1 and cortical neuron differentiation. | lld:pubmed |
| pubmed-article:16314515 | pubmed:affiliation | Center for Neuronal Survival, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada. | lld:pubmed |
