| pubmed-article:16301619 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16301619 | lifeskim:mentions | umls-concept:C0079488 | lld:lifeskim |
| pubmed-article:16301619 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:16301619 | lifeskim:mentions | umls-concept:C0079904 | lld:lifeskim |
| pubmed-article:16301619 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:16301619 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:16301619 | lifeskim:mentions | umls-concept:C1515877 | lld:lifeskim |
| pubmed-article:16301619 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:16301619 | lifeskim:mentions | umls-concept:C1523987 | lld:lifeskim |
| pubmed-article:16301619 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:16301619 | pubmed:dateCreated | 2005-11-22 | lld:pubmed |
| pubmed-article:16301619 | pubmed:abstractText | Helicobacter pylori causes various gastroduodenal diseases including gastric MALT lymphoma, but the mechanism underlying H. pylori-induced carcinogenesis is not known. The alternative pathway for NF-kappaB activation, which involves the processing of NF-kappaB2/p100 to p52, has been implicated in lymphocyte survival, attenuated apoptosis, and secondary lymphoid tissue development. In this study, we investigated H. pylori-induced activation of NF-kappaB through the alternative pathway in B lymphocytes. In immunoblot and EMSA, H. pylori induced NF-kappaB2/p100 processing to p52 and subsequent nuclear accumulation in IM-9 (human B cell line) cells and human peripheral blood B cells, but not in AGS (human gastric cancer cell line) cells. The activation of the alternative pathway was LPS-dependent but not cag pathogenicity island-dependent. Alternative pathway activation by H. pylori was associated with attenuated apoptosis. The expression levels of B lymphocyte chemoattractant, EBI-1 ligand chemokine, and stromal cell-derived factor-1alpha mRNAs were up-regulated in cocultured human B cells and in infected human gastric mucosa. In the infected mucosa, NF-kappaB2/p100 and p52 were detected immunohistochemically in the cytoplasm and nuclear compartments of lymphocytes, but not in epithelial cells. In summary, H. pylori activates the alternative NF-kappaB pathway in B lymphocytes. The effects on chemokine production and antiapoptosis mediated by H. pylori-induced processing of NF-kappaB2/p100 to p52 may drive lymphocytes to acquire malignant potential. | lld:pubmed |
| pubmed-article:16301619 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16301619 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16301619 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:16301619 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16301619 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16301619 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16301619 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16301619 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16301619 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16301619 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16301619 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16301619 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16301619 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16301619 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16301619 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16301619 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:16301619 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:16301619 | pubmed:author | pubmed-author:OmataMasaoM | lld:pubmed |
| pubmed-article:16301619 | pubmed:author | pubmed-author:MaedaShinS | lld:pubmed |
| pubmed-article:16301619 | pubmed:author | pubmed-author:OguraKeijiK | lld:pubmed |
| pubmed-article:16301619 | pubmed:author | pubmed-author:HirataYoshihi... | lld:pubmed |
| pubmed-article:16301619 | pubmed:author | pubmed-author:YoshidaHaruhi... | lld:pubmed |
| pubmed-article:16301619 | pubmed:author | pubmed-author:KawabeTakaoT | lld:pubmed |
| pubmed-article:16301619 | pubmed:author | pubmed-author:YanaiAyakoA | lld:pubmed |
| pubmed-article:16301619 | pubmed:author | pubmed-author:ShibataWataru... | lld:pubmed |
| pubmed-article:16301619 | pubmed:author | pubmed-author:OhmaeTomoyaT | lld:pubmed |
| pubmed-article:16301619 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16301619 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:16301619 | pubmed:volume | 175 | lld:pubmed |
| pubmed-article:16301619 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16301619 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16301619 | pubmed:pagination | 7162-9 | lld:pubmed |
| pubmed-article:16301619 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:16301619 | pubmed:meshHeading | pubmed-meshheading:16301619... | lld:pubmed |
| pubmed-article:16301619 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16301619 | pubmed:articleTitle | Helicobacter pylori activates NF-kappaB via the alternative pathway in B lymphocytes. | lld:pubmed |
| pubmed-article:16301619 | pubmed:affiliation | Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Hongo, Tokyo, Japan. tohmae-tky@umin.ac.jp | lld:pubmed |
| pubmed-article:16301619 | pubmed:publicationType | Journal Article | lld:pubmed |
| entrez-gene:53859 | entrezgene:pubmed | pubmed-article:16301619 | lld:entrezgene |
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