| pubmed-article:16274720 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16274720 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:16274720 | lifeskim:mentions | umls-concept:C0021853 | lld:lifeskim |
| pubmed-article:16274720 | lifeskim:mentions | umls-concept:C0014264 | lld:lifeskim |
| pubmed-article:16274720 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:16274720 | lifeskim:mentions | umls-concept:C1802750 | lld:lifeskim |
| pubmed-article:16274720 | lifeskim:mentions | umls-concept:C1720154 | lld:lifeskim |
| pubmed-article:16274720 | lifeskim:mentions | umls-concept:C0205164 | lld:lifeskim |
| pubmed-article:16274720 | lifeskim:mentions | umls-concept:C1883709 | lld:lifeskim |
| pubmed-article:16274720 | lifeskim:mentions | umls-concept:C0057695 | lld:lifeskim |
| pubmed-article:16274720 | lifeskim:mentions | umls-concept:C0057693 | lld:lifeskim |
| pubmed-article:16274720 | lifeskim:mentions | umls-concept:C0303848 | lld:lifeskim |
| pubmed-article:16274720 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:16274720 | pubmed:dateCreated | 2006-5-8 | lld:pubmed |
| pubmed-article:16274720 | pubmed:abstractText | Garlic and its active components are known to possess antioxidant and antiinflammatory effects. The present study investigated the effects of garlic oil and its organosulfur compounds on endotoxin-induced intestinal mucosal damage. Wistar rats received by gavage 50 or 200 mg/kg body weight garlic oil (GO), 0.5 mmol/kg body weight diallyl disulfide or diallyl trisulfide, or the vehicle (corn oil; 2 ml/kg body weight) every other day for 2 weeks before being injected with endotoxin (i.p., 5 mg/kg body weight). Control rats were administered with corn oil and were injected with sterile saline. Samples for the measurement of proinflammatory cytokines were collected 3 h after injection, and all other samples were collected 18 h after injection. The low dose of GO suppressed endotoxin-induced inducible nitric oxide synthase (iNOS) activity, ulceration, and apoptosis in the intestinal mucosa (P < 0.05). The high dose of GO significantly lowered the peripheral level of nitrate/nitrite and endotoxin-induced iNOS activity in the intestinal mucosa (P < 0.05) but worsened intestinal mucosal damage accompanied by elevated peripheral proinflammatory cytokines. Diallyl trisulfide but not diallyl disulfide showed similar toxic effect as that of high-dose GO. These results suggest the preventive effect and possible toxicity of garlic oil and its organosulfur compounds in endotoxin-induced systemic inflammation and intestinal damage. | lld:pubmed |
| pubmed-article:16274720 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16274720 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16274720 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16274720 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16274720 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16274720 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16274720 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16274720 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16274720 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16274720 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16274720 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16274720 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16274720 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16274720 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16274720 | pubmed:month | May | lld:pubmed |
| pubmed-article:16274720 | pubmed:issn | 0041-008X | lld:pubmed |
| pubmed-article:16274720 | pubmed:author | pubmed-author:SheenLee-YanL... | lld:pubmed |
| pubmed-article:16274720 | pubmed:author | pubmed-author:LiiChong-Kuei... | lld:pubmed |
| pubmed-article:16274720 | pubmed:author | pubmed-author:LiuCheng-TzuC... | lld:pubmed |
| pubmed-article:16274720 | pubmed:author | pubmed-author:ChiangYi-Hsua... | lld:pubmed |
| pubmed-article:16274720 | pubmed:author | pubmed-author:JenLin-NiLN | lld:pubmed |
| pubmed-article:16274720 | pubmed:author | pubmed-author:SuHsiau-YuanH... | lld:pubmed |
| pubmed-article:16274720 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16274720 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:16274720 | pubmed:volume | 213 | lld:pubmed |
| pubmed-article:16274720 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16274720 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16274720 | pubmed:pagination | 46-54 | lld:pubmed |
| pubmed-article:16274720 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:16274720 | pubmed:meshHeading | pubmed-meshheading:16274720... | lld:pubmed |
| pubmed-article:16274720 | pubmed:meshHeading | pubmed-meshheading:16274720... | lld:pubmed |
| pubmed-article:16274720 | pubmed:meshHeading | pubmed-meshheading:16274720... | lld:pubmed |
| pubmed-article:16274720 | pubmed:meshHeading | pubmed-meshheading:16274720... | lld:pubmed |
| pubmed-article:16274720 | pubmed:meshHeading | pubmed-meshheading:16274720... | lld:pubmed |
| pubmed-article:16274720 | pubmed:meshHeading | pubmed-meshheading:16274720... | lld:pubmed |
| pubmed-article:16274720 | pubmed:meshHeading | pubmed-meshheading:16274720... | lld:pubmed |
| pubmed-article:16274720 | pubmed:meshHeading | pubmed-meshheading:16274720... | lld:pubmed |
| pubmed-article:16274720 | pubmed:meshHeading | pubmed-meshheading:16274720... | lld:pubmed |
| pubmed-article:16274720 | pubmed:meshHeading | pubmed-meshheading:16274720... | lld:pubmed |
| pubmed-article:16274720 | pubmed:meshHeading | pubmed-meshheading:16274720... | lld:pubmed |
| pubmed-article:16274720 | pubmed:meshHeading | pubmed-meshheading:16274720... | lld:pubmed |
| pubmed-article:16274720 | pubmed:meshHeading | pubmed-meshheading:16274720... | lld:pubmed |
| pubmed-article:16274720 | pubmed:meshHeading | pubmed-meshheading:16274720... | lld:pubmed |
| pubmed-article:16274720 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16274720 | pubmed:articleTitle | Effects of garlic oil and two of its major organosulfur compounds, diallyl disulfide and diallyl trisulfide, on intestinal damage in rats injected with endotoxin. | lld:pubmed |
| pubmed-article:16274720 | pubmed:affiliation | Department of Nutrition, Chung Shan Medical University, No. 110, Sec. 1, Chien Kuo N. Road Taichung, Taiwan 402, Republic of China. | lld:pubmed |
| pubmed-article:16274720 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16274720 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16274720 | lld:pubmed |
