Linked Life Data

16239120

Source:http://linkedlifedata.com/resource/pubmed/id/16239120

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:16239120rdf:typepubmed:Citationlld:pubmed
pubmed-article:16239120lifeskim:mentionsumls-concept:C0030705lld:lifeskim
pubmed-article:16239120lifeskim:mentionsumls-concept:C0087111lld:lifeskim
pubmed-article:16239120lifeskim:mentionsumls-concept:C0282554lld:lifeskim
pubmed-article:16239120lifeskim:mentionsumls-concept:C0079189lld:lifeskim
pubmed-article:16239120lifeskim:mentionsumls-concept:C1704632lld:lifeskim
pubmed-article:16239120lifeskim:mentionsumls-concept:C0871261lld:lifeskim
pubmed-article:16239120lifeskim:mentionsumls-concept:C0014323lld:lifeskim
pubmed-article:16239120lifeskim:mentionsumls-concept:C0002826lld:lifeskim
pubmed-article:16239120lifeskim:mentionsumls-concept:C0012518lld:lifeskim
pubmed-article:16239120lifeskim:mentionsumls-concept:C2911692lld:lifeskim
pubmed-article:16239120lifeskim:mentionsumls-concept:C1706817lld:lifeskim
pubmed-article:16239120lifeskim:mentionsumls-concept:C0392747lld:lifeskim
pubmed-article:16239120lifeskim:mentionsumls-concept:C2630947lld:lifeskim
pubmed-article:16239120pubmed:issue1lld:pubmed
pubmed-article:16239120pubmed:dateCreated2006-1-30lld:pubmed
pubmed-article:16239120pubmed:abstractTextThis study examined the impact of concurrent parasite infections (amoebiasis, filariasis, necatoriasis) and the effect of anti-parasite treatment on cytokine and chemokine responses in singly and poly-parasitized patients. Cellular reactivity and parasite-specific Th1- and Th2-type cytokine and chemokine profiles were investigated before and six weeks after treatment. In those patients infected with three parasite species, cellular secretion of interleukin 5 (IL-5) and IL-12p40 by PBMC was strongly diminished (p<0.005) but IL-10 was elevated in parasite-infected patients (p<0.0001) in response to protozoa- and helminth-specific as well as bacteria-specific antigens. Macrophage inflammatory chemokines (MIP-1alpha/CCL3 and MIP-1beta/CCL4), macrophage-derived chemokine (MDC/CCL22) and neutrophil activating chemokine (IL-8/CXCL8) were produced by PBMC in similar amounts in endemic controls and singly and poly-parasitized patients, but thymus and activation-regulated chemokine (TARC/CCL17) was produced the highest by PBMC from patients with triple parasite infections (p<0.0001). Following anti-parasite therapy, secretion of IL-12p40 and IL-5 augmented significantly in treated patients while IL-10, MDC, MIP-1alpha, TARC and IL-8 substantially diminished (all p<10(-5)) when their PBMC were activated with parasite- and bacteria-specific antigens. In summary, PBMC from poly-parasitized patients responded to protozoa- and helminth-specific antigens with a compromised IL-5 and IL-12p40 but high IL-10 and a substantial chemokine release. Chemokines may attract and activate effector cells in peri-parasitic tissues to limit parasite proliferation and dissemination, while depressed IL-5 and IL-12p40 but prominent IL-10 may prevent eosinophil and cytotoxic cell-mediated inflammatory processes and pathogenesis to the host. The changes in this profile following anti-parasite therapy disclosed the dynamics of an immune adaptation associated with parasite accumulation and also with clearance of parasite infections.lld:pubmed
pubmed-article:16239120pubmed:languageenglld:pubmed
pubmed-article:16239120pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16239120pubmed:citationSubsetIMlld:pubmed
pubmed-article:16239120pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16239120pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16239120pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16239120pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16239120pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16239120pubmed:statusMEDLINElld:pubmed
pubmed-article:16239120pubmed:monthJanlld:pubmed
pubmed-article:16239120pubmed:issn1286-4579lld:pubmed
pubmed-article:16239120pubmed:authorpubmed-author:Schulz-KeyHar...lld:pubmed
pubmed-article:16239120pubmed:authorpubmed-author:SoboslayPeter...lld:pubmed
pubmed-article:16239120pubmed:authorpubmed-author:BanlaMebaMlld:pubmed
pubmed-article:16239120pubmed:authorpubmed-author:HammDavid MDMlld:pubmed
pubmed-article:16239120pubmed:authorpubmed-author:PfäfflinFried...lld:pubmed
pubmed-article:16239120pubmed:authorpubmed-author:FendtJuliaJlld:pubmed
pubmed-article:16239120pubmed:issnTypePrintlld:pubmed
pubmed-article:16239120pubmed:volume8lld:pubmed
pubmed-article:16239120pubmed:ownerNLMlld:pubmed
pubmed-article:16239120pubmed:authorsCompleteYlld:pubmed
pubmed-article:16239120pubmed:pagination238-47lld:pubmed
pubmed-article:16239120pubmed:dateRevised2006-11-15lld:pubmed
pubmed-article:16239120pubmed:meshHeadingpubmed-meshheading:16239120...lld:pubmed
pubmed-article:16239120pubmed:meshHeadingpubmed-meshheading:16239120...lld:pubmed
pubmed-article:16239120pubmed:meshHeadingpubmed-meshheading:16239120...lld:pubmed
pubmed-article:16239120pubmed:meshHeadingpubmed-meshheading:16239120...lld:pubmed
pubmed-article:16239120pubmed:meshHeadingpubmed-meshheading:16239120...lld:pubmed
pubmed-article:16239120pubmed:meshHeadingpubmed-meshheading:16239120...lld:pubmed
pubmed-article:16239120pubmed:meshHeadingpubmed-meshheading:16239120...lld:pubmed
pubmed-article:16239120pubmed:meshHeadingpubmed-meshheading:16239120...lld:pubmed
pubmed-article:16239120pubmed:meshHeadingpubmed-meshheading:16239120...lld:pubmed
pubmed-article:16239120pubmed:meshHeadingpubmed-meshheading:16239120...lld:pubmed
pubmed-article:16239120pubmed:meshHeadingpubmed-meshheading:16239120...lld:pubmed
pubmed-article:16239120pubmed:meshHeadingpubmed-meshheading:16239120...lld:pubmed
pubmed-article:16239120pubmed:meshHeadingpubmed-meshheading:16239120...lld:pubmed
pubmed-article:16239120pubmed:meshHeadingpubmed-meshheading:16239120...lld:pubmed
pubmed-article:16239120pubmed:meshHeadingpubmed-meshheading:16239120...lld:pubmed
pubmed-article:16239120pubmed:year2006lld:pubmed
pubmed-article:16239120pubmed:articleTitleCytokine and chemokine responses in patients co-infected with Entamoeba histolytica/dispar, Necator americanus and Mansonella perstans and changes after anti-parasite treatment.lld:pubmed
pubmed-article:16239120pubmed:affiliationInstitute for Tropical Medicine, Wilhelmstr. 27, University of Tübingen, Germany. peter.soboslay@uni-tuebingen.delld:pubmed
pubmed-article:16239120pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:16239120pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16239120lld:pubmed