Linked Life Data

16206186

Source:http://linkedlifedata.com/resource/pubmed/id/16206186

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:16206186rdf:typepubmed:Citationlld:pubmed
pubmed-article:16206186lifeskim:mentionsumls-concept:C0035647lld:lifeskim
pubmed-article:16206186lifeskim:mentionsumls-concept:C0011923lld:lifeskim
pubmed-article:16206186lifeskim:mentionsumls-concept:C0031268lld:lifeskim
pubmed-article:16206186lifeskim:mentionsumls-concept:C0927232lld:lifeskim
pubmed-article:16206186lifeskim:mentionsumls-concept:C0032743lld:lifeskim
pubmed-article:16206186lifeskim:mentionsumls-concept:C0050423lld:lifeskim
pubmed-article:16206186lifeskim:mentionsumls-concept:C0597354lld:lifeskim
pubmed-article:16206186lifeskim:mentionsumls-concept:C1708632lld:lifeskim
pubmed-article:16206186lifeskim:mentionsumls-concept:C0539266lld:lifeskim
pubmed-article:16206186lifeskim:mentionsumls-concept:C1522485lld:lifeskim
pubmed-article:16206186lifeskim:mentionsumls-concept:C0302995lld:lifeskim
pubmed-article:16206186pubmed:issue4lld:pubmed
pubmed-article:16206186pubmed:dateCreated2005-10-10lld:pubmed
pubmed-article:16206186pubmed:abstractTextA series of brain uptake studies and PET imaging studies were conducted with the sigma(1) selective imaging agent, [(18)F]FBFPA. The results of the study indicate that this radiotracer readily crosses the blood-brain barrier and labels sigma(1) receptors in vivo. In vivo blocking studies with a sigma(1) selective ligand and a nonselective sigma(1)/sigma(2) receptor ligand indicates that [(18)F]FBFPA labels sigma(1) and not sigma(2) receptors in rodent brain. PET imaging studies demonstrated a high uptake in regions of rhesus monkey brain having a high density of sigma(1) receptors. The uptake of [(18)F]FBFPA was displaced by the sigma ligand, haloperidol (1 mg/kg, i.v.). In vivo blocking studies indicate that the progesterone blocked the brain uptake of [(18)F]FBFPA in rat brain. These data indicate that [(18)F]FBFPA is a potential radiotracer for imaging sigma(1) receptors in the CNS in vivo with PET.lld:pubmed
pubmed-article:16206186pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16206186pubmed:languageenglld:pubmed
pubmed-article:16206186pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16206186pubmed:citationSubsetIMlld:pubmed
pubmed-article:16206186pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16206186pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16206186pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16206186pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16206186pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16206186pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16206186pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16206186pubmed:statusMEDLINElld:pubmed
pubmed-article:16206186pubmed:monthDeclld:pubmed
pubmed-article:16206186pubmed:issn0887-4476lld:pubmed
pubmed-article:16206186pubmed:authorpubmed-author:DuaG LGLlld:pubmed
pubmed-article:16206186pubmed:authorpubmed-author:GageH...lld:pubmed
pubmed-article:16206186pubmed:authorpubmed-author:MachRobert...lld:pubmed
pubmed-article:16206186pubmed:authorpubmed-author:BuchheimerNan...lld:pubmed
pubmed-article:16206186pubmed:authorpubmed-author:EhrenkauferRi...lld:pubmed
pubmed-article:16206186pubmed:authorpubmed-author:HuangYunsheng...lld:pubmed
pubmed-article:16206186pubmed:authorpubmed-author:KuhnerRossRlld:pubmed
pubmed-article:16206186pubmed:authorpubmed-author:MortonThomas...lld:pubmed
pubmed-article:16206186pubmed:copyrightInfoCopyright 2005 Wiley-Liss, Inc.lld:pubmed
pubmed-article:16206186pubmed:issnTypePrintlld:pubmed
pubmed-article:16206186pubmed:day15lld:pubmed
pubmed-article:16206186pubmed:volume58lld:pubmed
pubmed-article:16206186pubmed:ownerNLMlld:pubmed
pubmed-article:16206186pubmed:authorsCompleteYlld:pubmed
pubmed-article:16206186pubmed:pagination267-74lld:pubmed
pubmed-article:16206186pubmed:dateRevised2007-11-14lld:pubmed
pubmed-article:16206186pubmed:meshHeadingpubmed-meshheading:16206186...lld:pubmed
pubmed-article:16206186pubmed:meshHeadingpubmed-meshheading:16206186...lld:pubmed
pubmed-article:16206186pubmed:meshHeadingpubmed-meshheading:16206186...lld:pubmed
pubmed-article:16206186pubmed:meshHeadingpubmed-meshheading:16206186...lld:pubmed
pubmed-article:16206186pubmed:meshHeadingpubmed-meshheading:16206186...lld:pubmed
pubmed-article:16206186pubmed:meshHeadingpubmed-meshheading:16206186...lld:pubmed
pubmed-article:16206186pubmed:meshHeadingpubmed-meshheading:16206186...lld:pubmed
pubmed-article:16206186pubmed:meshHeadingpubmed-meshheading:16206186...lld:pubmed
pubmed-article:16206186pubmed:meshHeadingpubmed-meshheading:16206186...lld:pubmed
pubmed-article:16206186pubmed:meshHeadingpubmed-meshheading:16206186...lld:pubmed
pubmed-article:16206186pubmed:meshHeadingpubmed-meshheading:16206186...lld:pubmed
pubmed-article:16206186pubmed:meshHeadingpubmed-meshheading:16206186...lld:pubmed
pubmed-article:16206186pubmed:meshHeadingpubmed-meshheading:16206186...lld:pubmed
pubmed-article:16206186pubmed:meshHeadingpubmed-meshheading:16206186...lld:pubmed
pubmed-article:16206186pubmed:year2005lld:pubmed
pubmed-article:16206186pubmed:articleTitleN-[18F]4'-fluorobenzylpiperidin-4yl-(2-fluorophenyl) acetamide ([18F]FBFPA): a potential fluorine-18 labeled PET radiotracer for imaging sigma-1 receptors in the CNS.lld:pubmed
pubmed-article:16206186pubmed:affiliationDepartment of Radiology-PET Center Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA. rhmach@mir.wustl.edulld:pubmed
pubmed-article:16206186pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:16206186pubmed:publicationTypeResearch Support, N.I.H., Extramurallld:pubmed