| pubmed-article:161897 | pubmed:abstractText | In 11 mongrel dogs (10-15 kg) with ligated superficial femoral arteries the formation of collaterals induced by increased arterial pressure with an extracorporal circulation was studied. In general anesthesia a teflon tube was inserted into one deep femoral artery. The other end of this tube war introduced through the right carotid artery into the thoracic aorta and arterial blood was drawn by a peristaltic tube pump from the aorta to the femoral artery. Different arterial pressures created by the pump were used to perfuse this hind limb. After 40 minutes perfusion time with 200 mmHG pressure, there was marked increase of collateralization by the deep femoral artery. At the contralateral non treated side, only minimal development of collaterals was visualized. These angiograms demonstrate that collaterals are opened by increased pressure within a short time interval The experimental model might have clinical implisations and accelerate collateral formation in non-surgical treatment of arterial occlusive disease. | lld:pubmed |
