| pubmed-article:16186799 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16186799 | lifeskim:mentions | umls-concept:C1510411 | lld:lifeskim |
| pubmed-article:16186799 | lifeskim:mentions | umls-concept:C1420020 | lld:lifeskim |
| pubmed-article:16186799 | lifeskim:mentions | umls-concept:C0301625 | lld:lifeskim |
| pubmed-article:16186799 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:16186799 | pubmed:dateCreated | 2006-2-3 | lld:pubmed |
| pubmed-article:16186799 | pubmed:abstractText | The v-rel oncogene is the most efficient transforming member of the Rel/NF-kappaB family of transcription factors. v-Rel induces avian and mammalian lymphoid cell tumors and transforms chicken embryo fibroblasts in culture by the aberrant regulation of genes under the control of Rel/NF-kappaB proteins. Here we report that the expression of SH3BGRL, a member of the SH3BGR (SH3 domain-binding glutamic acid-rich) family of proteins, is downregulated in v-Rel-expressing fibroblasts, lymphoid cells, and splenic tumor cells. Chromatin immunoprecipitation experiments demonstrated that v-Rel binds to the sh3bgrl promoter in transformed cells. Coexpression of SH3BGRL with v-Rel in primary splenic lymphocytes reduced the number of colonies formed by 76%. Mutations in the predicted SH3-binding domain of SH3BGRL abolished the suppressive effect on v-Rel transformation and resulted in colony numbers comparable to those formed by v-Rel alone. However, mutations in the predicted EVH1-binding domain of SH3BGRL only had a modest effect on suppression of v-Rel transformation. This study provides the first example of a gene that is downregulated in v-Rel-expressing cells that also plays a role in v-Rel transformation. | lld:pubmed |
| pubmed-article:16186799 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16186799 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16186799 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16186799 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16186799 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16186799 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16186799 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16186799 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16186799 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:16186799 | pubmed:issn | 0950-9232 | lld:pubmed |
| pubmed-article:16186799 | pubmed:author | pubmed-author:MauckH PHP | lld:pubmed |
| pubmed-article:16186799 | pubmed:author | pubmed-author:BoseH RHR | lld:pubmed |
| pubmed-article:16186799 | pubmed:author | pubmed-author:YonJJ | lld:pubmed |
| pubmed-article:16186799 | pubmed:author | pubmed-author:LissA SAS | lld:pubmed |
| pubmed-article:16186799 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16186799 | pubmed:day | 2 | lld:pubmed |
| pubmed-article:16186799 | pubmed:volume | 25 | lld:pubmed |
| pubmed-article:16186799 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16186799 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16186799 | pubmed:pagination | 756-68 | lld:pubmed |
| pubmed-article:16186799 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:16186799 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16186799 | pubmed:articleTitle | The suppression of SH3BGRL is important for v-Rel-mediated transformation. | lld:pubmed |
| pubmed-article:16186799 | pubmed:affiliation | Section of Molecular Genetics and Microbiology, Institute of Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712-1095, USA. | lld:pubmed |
| pubmed-article:16186799 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16186799 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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